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The digestion patterns with 3 restriction endonucleases, <jats:italic>Sac<\/jats:italic> I, <jats:italic>Eco<\/jats:italic> RI and <jats:italic>Pst<\/jats:italic> I, of the proviruses integrated in T\u2010lymphoid cell lines derived from the CSF of 4 HAM patients were similar to those of HTLV\u20101 from adult T\u2010cell leukemia (ATL) patients. Integrated proviruses in one of these cell lines derived from the CSF were further analyzed in detail with 2 more restriction enzymes, <jats:italic>Bam<\/jats:italic>HI and <jats:italic>Sma<\/jats:italic> I. The results indicate that the retrovirus found in lymphocytes of the CSF from patients with HAM are very similar, if not identical, to HTLV\u2010I found in the leukemic lymphocytes of ATL patients.<\/jats:p>","DOI":"10.1002\/ijc.2910420213","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:17:42Z","timestamp":1171919862000},"page":"221-224","source":"Crossref","is-referenced-by-count":15,"title":["DNA blotting analysis of human retroviruses in cerebrospinal fluid of spastic paraparesis patients: The viruses are identical to human T\u2010cell leukemia virus type\u20101 (HTLV\u20101)"],"prefix":"10.1002","volume":"42","author":[{"given":"Jun","family":"Imamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumi","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitada","family":"Shimotohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91984-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91626-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90218-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90081-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(86)90278-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350510"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/308467a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.3.425"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/jvi.60.3.910-919.1986","article-title":"Cas\u2010Br\u2010E murine leukemia virus: sequencing of the paralytogenic region and the structure of its recombinant genomes in leukemic tissues","volume":"60","author":"Rassart E.","year":"1986","journal-title":"J. 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