{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:08:54Z","timestamp":1760645334225},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated protein synthesis in mouse tumor\u2010host liver is the net result of both stimulatory and inhibitory responses. This study compares the directional change in transcription and synthesis of liver and plasma proteins in tumor\u2010host liver as compared with para\u2010neoplastic conditions, such as malnutrition, inflammation, benign cell proliferation and protein deficiency. A methylcholanthrene\u2010induced sarcoma was used in weight stable mice (C57B1\/6J). Inflammation was induced by s. c. turpentine injection, and benign cell proliferation by injection of heat\u2010killed <jats:italic>Corynebacterium parvum<\/jats:italic>. DNA\u2010dependent RNA\u2010polymerase activity (I, II and III) (EC2.7. 7.6) was measured in isolated hepatic nuclei. Protein synthesis was measured by labelling of hepatic and plasma proteins following the injection of a \u201cflooding dose\u201d of the labelled amino acid. Benign hepatic cell proliferation and sterile inflammation caused increased rates of transcription, while malnourished and healthy control animals had lower hepatic transcription than animals bearing a malignant tumor. Inflammation was associated with increased activities of free (nonchromatin engaged) RNA polymerase, which was not found in any other para\u2010neoplastic condition or in the tumor\u2010host liver. A protein\u2010 and calorie\u2010deficient state was associated with depressed hepatic and plasma protein synthesis compared with the tumor condition. Tumor\u2010host livers had a nonsecretory protein synthesis rate equal to that of normal livers, but 45% higher plasma protein synthesis. Animals with inflammation and benign cell growth had liver protein synthesis rates which were approximately 50% higher than in tumorbearing animals, but plasma protein synthesis in tumor\u2010bearing animals was comparable with that of animals which had inflammation. Benign cell growth was not associated with an overall elevated plasma protein synthesis. The translation rate per transcription activity was highest in normal animals and decreased in animals suffering from either tumor, protein deficiency or benign cell proliferation. Hepatic protein synthesis in tumor\u2010host livers is high considering the degree of anorexia and malnutrition, although not as high as in livers from animals with pronounced inflammation. This counter\u2010regulation in tumor\u2010host livers may indicate a compensatory state to maintain protein synthesis against attenuating factors such as the declining food intake. Protein metabolism in tumorhost livers represents an unusual combination of findings.<\/jats:p>","DOI":"10.1002\/ijc.2910420326","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:15:48Z","timestamp":1171919748000},"page":"464-469","source":"Crossref","is-referenced-by-count":6,"title":["RNA polymerase activity and protein synthesis in mouse tumor\u2010host liver compared to benign para\u2010neoplastic reactions"],"prefix":"10.1002","volume":"42","author":[{"given":"Marie","family":"Ternell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Zachrisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent","family":"Lundholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000386029"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1330797"},{"key":"e_1_2_1_4_1","first-page":"305","article-title":"Macrophage activation and generation of tumoricidal activity by Iiposome\u2010Associated human C\u2010Reactive protein","volume":"44","author":"Barna B. 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