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The cell lines differed in the level of EBNA\u2010I expression and the size of the protein. The internal major late promoter of adenovirus was efficient in directing the transcription of EBNA\u2010I in the human lymphoma line BJAB, the murine T\u2010cell lymphoma Tikaut, RBL\u2010S, EL\u20104 and in the mouse sarcoma line MSWBS but was less efficient in Ramos, an EBV negative Burkitt lymphoma line, the human T\u2010cell leukemia line 1301TK and the P815\u2010X2 mouse mastocytoma line. All transfected lines except MSWBS contained EBNA\u2010I in a truncated form. The truncated EBNA\u2010I polypeptide reacted with the conventional human antibody reagents in an EBNA specific fashion but failed to bind rabbit or human antibody directed against the glycine\u2010alanine repeat sequence. MSWBS contained a truncated as well as a full size EBNA\u2010I polypeptide. It also reacted with antibody directed against the glycinealanine repeat. 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