{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:08:55Z","timestamp":1760645335266},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6453,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our previous study demonstrated that total parenteral nutrition (TPN) increases erythrocyte (RBC) polyamines selectively in cancer patients but not in non\u2010cancer patients, suggesting that these changes may relate to tumor presence. We therefore studied the possible relationship between RBC polyamine levels and potential tumor growth induced by TPN. In addition, we attempted to control tumor growth during TPN with \u03b1\u2010difluoromethylornithine (DFMO), a suicide inhibitor of ornithine decarboxylase (ODC), in a fibrosarcoma\u2010bearing rat model. Rats in a control group received chow <jats:italic>ad libitum<\/jats:italic> for 3 weeks and their tumors grew exponentially. A restricted intake (RI) tumor\u2010bearing group received 8 g chow per day per rat; this produced malnourished rats in which tumor growth significantly slowed. The third group (RI \u2192 TPN) received the RI diet for 2 weeks and TPN for 1 week, which resulted in an increase in tumor growth. The last group (RI \u2192 TPN + DFMO) received a 2\u2010week RI regimen and 1\u2010week TPN plus DFMO regimen, which inhibited tumor growth to the level of the RI group due to the addition of DFMO (1 g\/kg\/day). Although the addition of TPN to the RI regimen markedly increased tumor ODC activity, as well as tumor putrescine and RBC putrescine levels, the addition of DFMO to the RI \u2192 TPN regimen entirely abolished these increases. Despite DFMO treatment, liver ODC activity in RI \u2192 TPN + DFMO group was unaffected. The plasma albumin level, an indicator of host nutrition, of the RI \u2192 TPN + DFMO group was significantly higher than that of the RI group. Liver, spleen, kidney and total body weights of the RI \u2192 TPN or RI \u2192 TPN + DFMO group were significantly higher than those of the RI group. These results indicate that TPN can enhance tumor growth in malnourished hosts and that the addition of DFMO to TPN can effectively control this TPN\u2010enhanced tumor growth, leading to preferential nutritional repletion of the host.<\/jats:p>","DOI":"10.1002\/ijc.2910420520","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:13:22Z","timestamp":1171919602000},"page":"744-747","source":"Crossref","is-referenced-by-count":5,"title":["Polyamine\u2010directed preferential nutritional repletion of normal tissues in tumor\u2010bearing hosts"],"prefix":"10.1002","volume":"42","author":[{"given":"Kenji","family":"Nishioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"V. 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