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Antigenically, MCCL was characterized as CD5<jats:sup>\u2212<\/jats:sup>, CD10<jats:sup>\u2212<\/jats:sup>, CD19<jats:sup>+<\/jats:sup>, CD20<jats:sup>+<\/jats:sup>, CD21<jats:sup>\u2212<\/jats:sup>, CD22<jats:sup>+<\/jats:sup>, CD30<jats:sup>\u2212<\/jats:sup>, CD37<jats:sup>+<\/jats:sup>, CDw40<jats:sup>+<\/jats:sup>, and by a frequent expression of CD11c and CD23, while other antigens were inconsistently expressed. The antigenic profiles of MCCL and FCCL showed statistically significant differences in 4\/14 distinct antigens. When the neoplastic cells of both tumor groups were compared with morphologically defined normal B\u2010cell types, the overall resemblance of their immunophenotypes was even closer between MCCL and sinusoidal (monocytoid) B cells than between FCCL and follicular\u2010center B cells. We conclude that MCCL is a lymphoma type distinct from FCCL, most probably representing a highly malignant neoplasm corresponding to sinusoidal B\u2010cell reaction.<\/jats:p>","DOI":"10.1002\/ijc.2910430104","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:12:56Z","timestamp":1171919576000},"page":"10-16","source":"Crossref","is-referenced-by-count":21,"title":["Immunophenotypic similarities of mediastinal clear\u2010cell lymphoma and sinusoidal (monocytoid) b cells"],"prefix":"10.1002","volume":"43","author":[{"given":"Peter","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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