{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:13:06Z","timestamp":1760170386024},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6392,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV) has long been implicated in nasopharyngeal carcinoma (NPC). Recent studies in our and other laboratories have shown a correlation between the disease and high antibody titers to EBV specific DNase. These data led us to also examine serial sera from healthy adults and patients with infectious mononucleosis or NPC, for their capacity to neutralize the EBV\u2010specific thymidine kinase (TK) activity from chemically induced EBV\u2010carrying human lymphoblastoid cells. Our results were the following: (i) sera were found that efficiently blocked the EBV\u2010specific TK activity of induced\u2010Raji TK \u2010 cell extracts, but not the host\u2010cell TK activity from EBV\u2010negative BJAB cells; (ii) a relationship appeared between high levels of EBV\u2010specific TK\u2010neutralizing activity in sera and NPC pathology, even though in this preliminary study the degrees of EBV\u2010induced TK\u2010blocking activity detected in sera were not significantly correlated with EBVspecific antibody titers; (iii) the EBV\u2010induced TK\u2010neutralizing activity was found in the main lgG fraction derived from NPC sera. These data must be compared with other known antibody responses to EBV for their clinical interest in NPC control.<\/jats:p>","DOI":"10.1002\/ijc.2910430111","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:12:56Z","timestamp":1171919576000},"page":"45-48","source":"Crossref","is-referenced-by-count":19,"title":["Relationship between nasopharyngeal carcinoma and high antibody titers to epstein\u2010barr virus\u2010specific thymidine kinase"],"prefix":"10.1002","volume":"43","author":[{"given":"Mireille","family":"De Turenne\u2010Tessier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamasa","family":"Ooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Calender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"De The","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Daillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890170107"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.6162"},{"key":"e_1_2_1_4_1","series-title":"IARC Scientific Publication 24","first-page":"899","volume-title":"Presence of antibody against Herpes simplex virus\u2010Specified thymidine kinase and deoxyribonuclease in human sera","author":"Cheng Y. C.","year":"1978"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(82)90011-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330103"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/jcm.15.3.366-371.1982","article-title":"Rapid typing of Herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeox\u2010Yuridine","volume":"15","author":"Gronowitz J. S.","year":"1982","journal-title":"J. clin. Microbiol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170102"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1128\/iai.36.1.30-37.1982","article-title":"Human serum antibodies to Varicella\u2010Zoster virus thymidine kinase","volume":"36","author":"Kallander C. F. R.","year":"1982","journal-title":"Infect. Immunol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4590-2_47"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04450.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149508"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290216"},{"key":"e_1_2_1_14_1","first-page":"149","article-title":"Deoxythymidine kinases in Varicella\u2010Zoster\u2010Virus\u2010Infected and biochemically transformed cells","volume":"25","author":"Ogino T.","year":"1982","journal-title":"Biken J."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/jvi.46.1.187-195.1983","article-title":"Effect of arabinofuranosylthymine on the replication of Epstein\u2010Barr virus and relationship with a new induced thymine kinase activity","volume":"46","author":"Ooka T.","year":"1983","journal-title":"J. Virol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/jvi.49.2.626-628.1984","article-title":"Epstein\u2010Barr\u2010Virus\u2010Specific DNase activity in non\u2010Producer Raji cells after treatment with 12\u20130\u2010Tetradecanoylphorbol\u201013\u2010Acetate and sodium butyrate","volume":"49","author":"Ooka T.","year":"1984","journal-title":"J. Virol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830115)51:2<260::AID-CNCR2820510216>3.0.CO;2-#"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300505"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/jvi.44.3.893-899.1982","article-title":"Identification and characterization of a DNase induced by Epstein\u2010Barr virus","volume":"44","author":"Tan R. S.","year":"1982","journal-title":"J. Virol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4163-5_2"},{"key":"e_1_2_1_21_1","first-page":"236","volume-title":"The Epstein\u2010Barr virus: recent advances","author":"DeTh\u00e9 G.","year":"1986"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1128\/jvi.57.3.1105-1112.1986","article-title":"Characterization of an Epstein\u2010Barr\u2010Virus\u2010Induced thymidine kinase","volume":"57","author":"De Turenne\u2010Tessier M.","year":"1986","journal-title":"J. Virol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290204"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.6.2707"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910430111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910430111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T03:03:48Z","timestamp":1697943828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910430111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,15]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1,15]]}},"alternative-id":["10.1002\/ijc.2910430111"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910430111","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1,15]]}}}