{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:55:06Z","timestamp":1791312906805,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6361,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATL), a malignancy of mature CD4\u2010positive lymphocytes, has been etiologically linked to the human retrovirus HTLV\u2010I. Although a long latent period is suggested from migrant studies, little prospective information on the risk of developing ATL among persons with HTLV\u2010I infection is available. We present here a model for ATL risk based upon age\u2010 and sex\u2010specific HTLV\u2010I seroprevalence data from a cross\u2010sectional survey of 13,000 Jamaicans and ATL incidence data from a 21\/2\u2010year case\u2010control study. By examining the age\u2010specific incidence of ATL relative to both adult and childhood\u2010acquired seropositivity <jats:italic>versus<\/jats:italic> childhood\u2010acquired seropositivity alone, we provide evidence in support of the hypothesis that childhood infection with HTLV\u2010I is important to the development of ATL. Using this model, the cumulative lifetime risk of ATL for those infected before age 20 is estimated to be 4.0% for males and 4.2% for females. Under this hypothesis, HTLV\u2010I\u2010associated diseases with shorter latent periods, such as tropical spastic paraparesis, should have a higher incidence in adult females than in adult males.<\/jats:p>","DOI":"10.1002\/ijc.2910430214","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:10:22Z","timestamp":1171919422000},"page":"250-253","source":"Crossref","is-referenced-by-count":325,"title":["Modelling the risk of adult T\u2010cell leukemia\/lymphoma in persons infected with human T\u2010lymphotropic virus type I"],"prefix":"10.1002","volume":"43","author":[{"given":"E. L.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. N.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. S.","family":"Lofters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Goedert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Viral infections of humans, epidemiology and control","author":"Blattner W. A.","year":"1989"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4895"},{"key":"e_1_2_1_4_1","first-page":"668","volume-title":"Cancer epidemiology and prevention","author":"Falk H.","year":"1982"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-3-361"},{"key":"e_1_2_1_7_1","first-page":"362","volume-title":"Oncogenic viruses","author":"Gross L.","year":"1983"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92358-0"},{"key":"e_1_2_1_9_1","first-page":"259","article-title":"Risk of adult T\u2010Cell leukemia\/Lymphoma in HTLV\u2010I carriers. Letter to the Editor","author":"Kondo T.","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230739"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_2_1_12_1","unstructured":"Riedel D. Blattner W. Evans A. Saxinger C. andGallo R. Household and sexual transmission of the human T\u2010Cell leukemia\/Lymphoma virus Type I(hTLV\u2010I) in Barbados 1972. Proceedings IV International Conference on AIDS p.255 Stockholm (1988)."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90778-0"},{"key":"e_1_2_1_14_1","unstructured":"Statistical Institute Of Jamaica.Population census 1970 Vol. 1 pp.3\u20136 Kingston Jamaica (1970)."},{"key":"e_1_2_1_15_1","unstructured":"Statistical Institute Of Jamaica.Population census 1982 Vol. 1 pp.3\u20134 Kingston Jamaica (1982)."},{"key":"e_1_2_1_16_1","first-page":"423","article-title":"Estimation of rate of incidence of ATL among ATLV (hTLV\u2010I) carriers in Kyushu, Japan","volume":"15","author":"Tajima K.","year":"1985","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_17_1","first-page":"893","article-title":"Epidemiological analysis of the distribution of antibody to adult T\u2010Cell leukemia virus\u2010Associated antigen: possible horizontal transmission of adult T\u2010Cell leukemia virus","volume":"73","author":"Tajima K.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_18_1","unstructured":"Tekse K. Population and vital statistics\u2014jamaica 1932\u20131964 historical perspective pp.48\u201349 56\u201357 Department of Statistics Kingston Jamaica (1974)."},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/oxfordjournals.jjco.a039079","article-title":"Statistical analyses of clinico\u2010Pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T\u2010Cell leukemia\/Lymphoma: a report of the second nationwide study of Japan","volume":"15","author":"THE T\u2010 and B\u2010Cell Malignancy Study Group","year":"1985","journal-title":"Jap. J. clin. 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