{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:36:48Z","timestamp":1761237408315},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6361,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Epstein\u2010Barr virus (EBV)\u2010negative Burkitt lymphoma (BL) line BL\u201041, and 5 independently established EBV\u2010converted sublines, derived by infection with a transforming (B95\u20108) or a nontransforming (P3HRI) strain of EBV, were compared for clonability in semi\u2010solid agarose and for tumorigenicity in immuno\u2010suppressed mice. One P3HRI viral convertant and 3 out of 4 B95\u20108 virus\u2010converted sublines had a high (&gt;40%) agarose clonability, like the BL 41 parent, and were slightly more tumorigenic than BL\u201041. In contrast, the fourth B95\u20108 converted subline, BL\u201041\/95, was virtually non\u2010tumorigenic and its agarose clonability was much lower (3\u201323%). It showed a more drastic shift towards an LCL\u2010like phenotype than the other convertants as reflected by high HLA class\u2010I and EBV\u2010encoded latent membrane protein (LMP) expression. BL 41\/95 still contains the 8;14 IgH\/<jats:italic>myc<\/jats:italic> translocation, carried by the parental line, and maintains the same relatively high steady\u2010state level of c\u2010<jats:italic>myc<\/jats:italic> mRNA and protein as the highly tumorigenic convertants. We conclude that the tumorigenicity of BL41\/95 has been suppressed by a gene that acts at a level beyond the expression of the activated oncogene, in the same way as the revertants isolated from <jats:italic>ras<\/jats:italic> and SV\u201040\u2010transformed cultures (Klein, 1987<jats:italic>b<\/jats:italic>; Bassin and Noda, 1987).<\/jats:p>","DOI":"10.1002\/ijc.2910430219","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:10:22Z","timestamp":1171919422000},"page":"273-278","source":"Crossref","is-referenced-by-count":25,"title":["Reversion of tumorigenicity and decreased agarose clonability after EBV conversion of an igh\/<i>myc<\/i> translocation\u2010carrying be line"],"prefix":"10.1002","volume":"43","author":[{"given":"Sigurbj\u00f6rg","family":"Torsteinsd\u00f3ttir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika L.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Avila\u2010Cari\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbro","family":"Ehlin\u2010Henriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Masucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400521"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_5_1","first-page":"103","article-title":"Oncogene inhibition by cellular genes","volume":"7","author":"Bassin R. 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