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In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more <jats:italic>ras<\/jats:italic> p21 was detected in the tumor than in its normal counterpart. Twenty\u2010five of 28 breast tumors demonstrated more <jats:italic>ras<\/jats:italic> p21 than the average of the values obtained for fibroadenomas. Furthermore, in 17 of the 19 cases studied, over 20% more <jats:italic>ras<\/jats:italic> p21 was observed in breast carcinomas compared with their respective normal counterparts. More <jats:italic>ras<\/jats:italic> p21 was also demonstrated in the majority of tumors of the stomach, lung, colon and bladder compared with their respective adjacent normal tissues. Our data therefore indicate that <jats:italic>ras<\/jats:italic> p21 expression is quantitatively enhanced in many human tumors originating from several different tissue types.<\/jats:p>","DOI":"10.1002\/ijc.2910430315","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:49:51Z","timestamp":1171921791000},"page":"431-435","source":"Crossref","is-referenced-by-count":27,"title":["Evidence of enhancement of the <i>ras<\/i> oncogene protein product (p21) in a spectrum of human tumors"],"prefix":"10.1002","volume":"43","author":[{"given":"F.","family":"De Biasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Del Sal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Horan Hand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/327293a0"},{"key":"e_1_2_1_3_1","first-page":"91","volume-title":"Carcinogenesis","author":"Burnus F. 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