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In 5 out of 23 meningiomas the <jats:italic>Eco<\/jats:italic> RI restriction of genomic DNAs revealed 6 invariant normal fragments of 6.5, 4.8, 3.8, 3.1, 2.7 and 1.7 kb, plus 2 additional variant fragments of either 8.6 or 2.5 kb. More detailed analysis showed that these variant bands hybridized with a probe specific for the middle region of the estrogen receptor cDNA, coding for the DNA\u2010binding domain of the receptor. This abnormal restriction pattern was found only in these meningiomas and not in other brain tumors or DNAs obtained from peripheral blood lymphocytes.<\/jats:p>","DOI":"10.1002\/ijc.2910430406","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:46:30Z","timestamp":1171921590000},"page":"567-569","source":"Crossref","is-referenced-by-count":4,"title":["Altered restriction pattern of the putative DNA binding domain of estrogen receptor or related genes in primary human meningiomas"],"prefix":"10.1002","volume":"43","author":[{"given":"A.","family":"Vacca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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