{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:37:17Z","timestamp":1766518637275},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The occurrence of cancer among the 1,348 offspring of 2,441 survivors of childhood cancer, treated before 1978, was investigated. Information was obtained through a questionnaire sent to the general practitioners of these survivors. Twenty\u2010three of 52 offspring born to survivors of heritable retinoblastoma developed retinoblastoma; the heritable form of retinoblastoma is known to be transmitted to offspring as an autosomal dominant. None of the 94 offspring born to the 54 survivors of unilateral retinoblastoma with no family history of the disease have developed the disease. This implies that it is unlikely that more than 9% of survivors of unilateral retinoblastoma with no family history have the germ\u2010cell mutation; consequently it is unlikely that more than 4% of their offspring will be affected. Among the 1,199 offspring born to 629 survivors of other childhood malignant disease, who produced children, one acute monocytic leukaemia and one acute lymphoblastic leukaemia were observed. This is more than expected on the basis of the general population (one\u2010tailed <jats:italic>p<\/jats:italic> = 0.04). However, the types of cancer observed in these 2 offspring and their parents conform to a previously described familial aggregation of cancers. Only a small number of children were born to survivors who received therapy that was potentially germ\u2010cell mutagenic, and thus it is not possible to make any accurate estimation of their risk of malignant disease.<\/jats:p>","DOI":"10.1002\/ijc.2910430604","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:45:23Z","timestamp":1171921523000},"page":"975-978","source":"Crossref","is-referenced-by-count":75,"title":["Cancer among 1,348 offspring of survivors of childhood cancer"],"prefix":"10.1002","volume":"43","author":[{"given":"M. M.","family":"Hawkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Draper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","series-title":"IARC Scientific Publication 82","volume-title":"The design and analysis of cohort studies","author":"Breslow N. E.","year":"1987"},{"key":"e_1_2_1_3_1","series-title":"IARC Scientific Publications","volume-title":"Perinatal and multigenerational carcinogenesis","author":"Draper G. J."},{"key":"e_1_2_1_4_1","first-page":"102","article-title":"Childhood cancer survivors and their offspring studied through a postal survey of general practitioners: preliminary results","volume":"38","author":"Hawkings M. M.","year":"1988","journal-title":"J. roy. Coll. Gen. Pract."},{"key":"e_1_2_1_5_1","first-page":"313","article-title":"Mutation and cancer: a model for Wilms' tumour of the kidney","volume":"48","author":"Knudson A. G.","year":"1972","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_6_1","first-page":"2692","article-title":"Prospective study of a family cancer syndrome","volume":"257","author":"Li F. P.","year":"1982","journal-title":"J. Amer. Med. Ass."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1542\/peds.81.1.147","article-title":"Heritable fraction of unilateral Wilms' tumour","volume":"81","author":"Li F. P.","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_1","first-page":"333","article-title":"Offspring of long\u2010Time survivors of childhood cancer","volume":"4","author":"Mulvihill J. J.","year":"1985","journal-title":"Clin Oncol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91012-9"},{"key":"e_1_2_1_10_1","volume-title":"Cancer registration surveillance 1969\u20101978 England and Wales","author":"Office Of Population Censuses and Surveys","year":"1983"},{"key":"e_1_2_1_11_1","series-title":"IARC Scientific Publication 87","volume-title":"International childhood cancer incidence","author":"Parkin D. M.","year":"1988"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268429"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295569"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910430604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910430604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T11:14:48Z","timestamp":1697973288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910430604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,15]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6,15]]}},"alternative-id":["10.1002\/ijc.2910430604"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910430604","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6,15]]}}}