{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:16:15Z","timestamp":1747746975940},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6241,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel murine tumor resistant to <jats:italic>cis<\/jats:italic>\u2010diamminedichloroplatinum (cisplatin, DDP) was obtained (M5\/DDP) after 22 passages in which mice bearing the ovarian reticular cell sarcoma M5076 (M5) were treated with DDP. Although DDP conserved some inhibitory activity on growth of M5\/DDP, it was much less effective than on M5. Treatment with DDP did not prolong the survival time of mice with M5\/DDP, whereas it markedly prolonged survival of M5\u2010bearing mice. MS and M5\/DDP tumors shared many biological and biochemical features. They were similar histologically, they metastasized reproducibly to the liver and were poorly immunogenic. Their growth rates were comparable; their DNA index, percentage of cells in S phase and intra\u2010cellular glutathione content were also similar. In both tumors, DDP caused an accumulation of cells in S late\u2010G<jats:sub>2<\/jats:sub>\u2010M within 24 hr after drug treatment. However, this was efficiently reversed in M5\/DDP, whereas it worsened and persisted longer in M5. Cross\u2010resistance was observed between DDP and its analogues carboplatin and iproplatin, but tetraplatin retained marginal activity on M5\/DDP tumor. Several alkylating agents tested [L\u2010phenylalanine mustard (L\u2010PAM); cyclophosphamide (CTX); chlorambucil (CLB); 1,3\u2010bis(2\u2010chloroethyl)\u2010I\u2010nitrosourea (BCNU) and dacarbazine (DTIC)] were not totally cross\u2010resistant to DDP, but showed greater activity on M5 than on M5\/DDP. Other non\u2010alkylating anti\u2010neoplastic drugs showed a similar degree of activity on M5 and M5\/DDP. 5\u2010Aza\u20102\u2032\u2010deoxycytidine (Aza\u2010d\u2010Cyd) was very effective on both tumors, etoposide (VP\u201016) and cytosine arabinoside (Ara\u2010C) had no activity and Adriamycin (ADR) was weakly effective.<\/jats:p>","DOI":"10.1002\/ijc.2910430623","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:45:23Z","timestamp":1171921523000},"page":"1091-1097","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of a novel mouse reticular cell sarcoma M5076 subline resistant to cisplatin"],"prefix":"10.1002","volume":"43","author":[{"given":"A.","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Damia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Erba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mandelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D'incalci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1361","article-title":"Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis\u2010Diamminedichloroplatinum(iI) in human glial\u2010Derived cell lines","volume":"47","author":"Aida T.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","first-page":"997","article-title":"Synthesis. physical properties, and anti\u2010Tumor activity of tetraplatin and related tetrachloroplatinum(iV) stereo\u2010Isomers of 1,2\u2010Diaminocyclohexane","volume":"70","author":"Anderson W. 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