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Metaphases were obtained from primary (10 B\u2010cell tumors) and first or second transplant generation lymphomas (6 B\u2010cell and 10 T\u2010cell tumors), all of which were well characterized with respect to phenotypic, histologic and genotypic features. In the T\u2010cell tumors we found relatively simple karyotypic abnormalities, including various numerical aberrations, such as trisomy 15, in line with many earlier reports. However, the majority of B\u2010cell tumors showed a great variety of both structural and numerical chromosomal anomalies. Three B\u2010cell lymphomas had an apparently normal karyotype. No single cytogenetic abnormality occurred commonly in the B\u2010cell lymphomas, but some structural abnormalities were found in more than one stemline, in particular, ins (11) (A1; A2) in 3 tumors, and deletions involving the D\u2010region of chromosome 14 in 3 other lymphomas. These cytogenetic results clearly indicate that the pathogenic mechanisms involved in MuLV\u2010induced (long latency) B\u2010cell lymphomagenesis and (short latency) T\u2010cell lymphomagenesis differ considerably.<\/jats:p>","DOI":"10.1002\/ijc.2910430626","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:45:23Z","timestamp":1171921523000},"page":"1112-1119","source":"Crossref","is-referenced-by-count":5,"title":["Distinct chromosomal abnormalities in murine leukemia virus\u2010induced T\u2010 and B\u2010cell lymphomas"],"prefix":"10.1002","volume":"43","author":[{"given":"W. L. E.","family":"Vasmel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P. 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