{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:02:41Z","timestamp":1698037361401},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6180,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 6 different Burkitt lymphoma cell lines with t(2;8) variant translocations (JI. LY66, LY9I, BL21, BL64, JBL2) the breakpoints on chromosome 8q<jats:sup>+<\/jats:sup> were mapped in relation to each other and to <jats:italic>c\u2010myc<\/jats:italic> by <jats:italic>in situ<\/jats:italic> hybridization. The probes used were derived from chromosome 8q24 and comprised a <jats:italic>c\u2010myc<\/jats:italic> probe, a probe located 48 kb downstream of <jats:italic>c\u2010myc<\/jats:italic>, 3 probes adjacent to the chromosomal breakpoints of BL64, LY91 and JBL2, respectively, and 2 probes located in the 5\u2032 and 3\u2032 part of the thyroglobulin gene. The breakpoints of LY91 and JBL2 lie &lt;200 kb and&gt;200 kb downstream of <jats:italic>c\u2010myc<\/jats:italic>, whereas the distance to <jats:italic>c\u2010myc<\/jats:italic> of the BL64 breakpoint and of the thyroglobulin probes is unknown. By recording the hybridization signals specific for these probes on chromosomes 2p<jats:sup>\u2212<\/jats:sup> and 8q<jats:sup>+<\/jats:sup>of each cell line it was possible to establish the order of breakpoints on band 8q24 relative to the <jats:italic>c\u2010myc<\/jats:italic> and thyroglobulin genes as follows: centromere\u2014c\u2010myc\u2014JI\u2014BL64\u2014BL21\u2014 LY91\u2014JBL2\u2014LY66\u2014thyroglobulin\u2014telomere. This information is essential for further mapping of this important chromosomal region.<\/jats:p>","DOI":"10.1002\/ijc.2910440213","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:40:04Z","timestamp":1171921204000},"page":"261-265","source":"Crossref","is-referenced-by-count":3,"title":["t(2;8) variant translocation in burkitt's lymphoma: Mapping of chromosomal breakpoints by <i>in situ<\/i> hybridization"],"prefix":"10.1002","volume":"44","author":[{"given":"Sabine","family":"Adolph","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Hameister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Henglein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Baas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293284"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/321702a0"},{"key":"e_1_2_1_4_1","first-page":"223","volume-title":"Cellular oncogene activation","author":"Bornkamm G. W.","year":"1988"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60200-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03682.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.11.3199"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.21.8331"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04140.x"},{"key":"e_1_2_1_11_1","first-page":"597","article-title":"The block of elongation in c\u2010 myc exon 1 is abolished in Burkitt's lymphoma cell lines with variant translocation","volume":"3","author":"Eick D.","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04578.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/314740a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90584-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292668"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.6.2037"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Henglein B. Synovzik H. Groitl P. Bornkamm G. W. Hartl P.andLipp M. Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma fall within a region 140 kb distal from c\u2010myc. Mol. cell. Biol (in press) (1989).","DOI":"10.1128\/MCB.9.5.2105"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/307752a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1031"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/306662a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.12.4877"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90862-7"},{"key":"e_1_2_1_23_1","series-title":"IARC Scientific Publication 60","first-page":"309","volume-title":"Burkitt's lymphoma: a human cancer model","author":"Lenoir G. M.","year":"1985"},{"key":"e_1_2_1_24_1","first-page":"733","article-title":"The phenomenon of position effect","volume":"3","author":"Lewis E. B.","year":"1950","journal-title":"Advanc. Genet."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90111-1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02458.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9123"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2984"},{"key":"e_1_2_1_29_1","first-page":"166","article-title":"The c\u2010myc gene paradox in Burkitt's lymphoma chromosomal translocation","volume":"193","author":"Rabbitts T. H.","year":"1984","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/309592a0"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02239.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2824"},{"key":"e_1_2_1_33_1","first-page":"955","volume-title":"The genetics and biology of","author":"Spofford J. B.","year":"1976"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.10.4037"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.11.4553"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90381-7"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90227-7"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.5.1834"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.21.6798"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910440213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910440213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T03:12:11Z","timestamp":1697944331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910440213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8,15]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,8,15]]}},"alternative-id":["10.1002\/ijc.2910440213"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910440213","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8,15]]}}}