{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:44:48Z","timestamp":1769604288520,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6149,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Implanted foreign bodies of certain shapes, especially large non\u2010perforated polymer films, induce subcutaneous sarcomas in a high percentage of mice and rats; in contrast, implants of other shapes, <jats:italic>e.g.<\/jats:italic>, perforated or minced films or Millipore filters with 0.45 \u03bcm pores, are non\u2010carcinogenic or only weakly carcinogenic. Experiments described in this report have shown that when carcinogenic non\u2010perforated film was removed at 3.5 months after implantation and one of the \u201cnon\u2010carcinogenic\u201d foreign bodies listed above was implanted into the same subcutaneous sites, a high percentage of sarcomas was induced. The same non\u2010carcinogenic or weakly carcinogenic foreign bodies implanted in the mice after total body \u03b3 irradiation or after single injection of ethylnitrosourea induced subcutaneous sarcomas in significantly higher percentages of animals than the same foreign bodies implanted in control mice. Our data suggest that foreign bodies of \u201cnon\u2010carcinogenic\u201d or \u201cweakly carcinogenic\u201d shapes can act as efficient promoters of subcutaneous carcinogenesis initiated by other agents such as implanted \u201ccarcinogenic\u201d foreign bodies, ionizing radiation or chemical carcinogen.<\/jats:p>","DOI":"10.1002\/ijc.2910440312","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:40:03Z","timestamp":1171921203000},"page":"449-453","source":"Crossref","is-referenced-by-count":19,"title":["Early and late stages of foreign\u2010body carcinogenesis can be induced by implants of different shapes"],"prefix":"10.1002","volume":"44","author":[{"given":"T. G.","family":"Moizhess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Vasiliev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Carcinogenesis as a biological problem","author":"Berenblum I.","year":"1974"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000385997"},{"key":"e_1_2_1_4_1","volume-title":"Cancer","author":"Brand K. G.","year":"1975"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/jnci\/57.5.973","article-title":"Diversity and complexity of carcinogenic process: conceptual inferences from foreign\u2010body tumorigenesis","volume":"57","author":"Brand K. G.","year":"1976","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_6_1","first-page":"663","article-title":"Carcinogenesis from polymer implants: new chromosomal and transplantation studies during premalig\u2010nancy","volume":"39","author":"Brand K. 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