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Replication of the intracellular Epstein\u2010Barr virus DNA was selectively inhibited in these ceils with only 15% of the viral genomes duplicating once to form hybrid\u2010density viral DNA. However, some heavy\u2010density viral DNA was formed in the U296 cells and DNA synthesis can thus initiate again on newly duplicated viral genomes in cells that have traversed only a single S phase. These results contrast strongly with observations concerning the Burkitt\u2010lymphoma\u2010derived cell line. Lymphoma cells are not growth\u2010inhibited and most of the latent Epstein\u2010Barr virus genomes of the Raji line replicated once, and only once, in successive S phases. While the majority of the 50 Epstein\u2010Barr virus genomes of both the Raji and U296 cell lines are maintained as extra\u2010chromosomal DNA plasmids, the control of their duplication is distinctly different in the respective malignant and non\u2010malignant host cells.<\/jats:p>","DOI":"10.1002\/ijc.2910440331","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:40:03Z","timestamp":1171921203000},"page":"560-564","source":"Crossref","is-referenced-by-count":6,"title":["Replication of latent Epstein\u2010Barr virus genomes in normal and malignant lymphoid cells"],"prefix":"10.1002","volume":"44","author":[{"given":"Alice","family":"Adams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara C.","family":"Pozos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen V.","family":"Purvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67236-1_8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.61.5.1743-1746.1987"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.10.2888"},{"key":"e_1_2_1_5_1","first-page":"13","volume-title":"The Epstein\u2010Barr virus, recent advances","author":"Dambaugh T.","year":"1986"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90008-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1128\/jvi.52.2.549-556.1984","article-title":"Electron microscopic evidence for replication of circular Epstein\u2010Barr virus genomes in latently infected Raji cells","volume":"52","author":"Gussander E.","year":"1984","journal-title":"J. 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