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Repeated irradiation of the XP cells, XP7NI, with UV\u2010light and subsequent treatment with l2\u20100\u2010tetradecanoylphorbol\u2010l3\u2010acetate (TPA) resulted in the acquisition of tumorigenicity in athymic nude mice. The tumorigenicity of XP7NI cells was also induced by TPA treatment alone. The tumors formed in athymic mice were of B\u2010cell lymphoma with characteristic histology, cell surface immunoglobulins and an antigen as detected by a B\u2010cell\u2010specific monoclonal antibody (MAb), CD20. The surface immunoglobulins and the HLA type of these tumor cells were identical with those of the parental cells. These malignantly transformed cells retained the same UV sensitivity, serum requirement, colony\u2010forming ability in soft agar, and normal human karyotype as the parental cells. Unlike other tumorigenic lymphoblastoid cell lines, this XP lympho\u2010blastoid cell line provides a unique case in that process(es) leading to tumorigenicity may be induced by UV and TPA without apparent karyotypic changes.<\/jats:p>","DOI":"10.1002\/ijc.2910440412","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:39:55Z","timestamp":1171921195000},"page":"629-633","source":"Crossref","is-referenced-by-count":3,"title":["Tumorigenic conversion of <i>xeroderma pigmentosum<\/i> lymphoblastoid cells without karyotypic alteration"],"prefix":"10.1002","volume":"44","author":[{"given":"Akira","family":"Tachibana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao S.","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Arita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiraku","family":"Takebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4382-0_10"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/218652a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211113072006"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.3.1147"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.3982"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/4.11.1389"},{"key":"e_1_2_1_8_1","first-page":"527","article-title":"Transformation of Epstein\u2010Barr\u2010virus\u2010immortalized human B\u2010cell by chemical carcinogens","volume":"47","author":"Kessler D. 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