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KH\u20102 cells are integrated by HTLV\u2010I proviral DNA and expressed mRNA for <jats:italic>c\u2010myc<\/jats:italic>, IL\u20102 receptor a\u2010chain (IL\u20102R\u03b1), and T\u2010cell receptor \u03b2\u2010chain (TCR\u03b2) while it did not express IL\u20102 mRNA. l,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> and dexamethasone did not suppress the mRNA levels of HTLV\u2010I, IL\u20102R\u03b1 or TCR\u03b2 but reduced the <jats:italic>c\u2010myc<\/jats:italic> mRNA level. The reduction of <jats:italic>c\u2010myc<\/jats:italic> mRNA level was marked in l,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>\u2010treated cells but relatively weak in dexamethasone\u2010treated cells. This inhibitory effect of the steroid hormones correlated with the inhibition of KH\u20102 cell proliferation.<\/jats:p>","DOI":"10.1002\/ijc.2910440425","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:39:55Z","timestamp":1171921195000},"page":"701-706","source":"Crossref","is-referenced-by-count":12,"title":["Suppression of <i>c\u2010myc<\/i> mRNA expression by steroid hormones in HTLV\u2010I\u2010infected T\u2010cell line, KH\u20102"],"prefix":"10.1002","volume":"44","author":[{"given":"Tamio","family":"Koizumi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakan","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6320374"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.133.1.273","article-title":"Dcxamcthasonemediated inhibition of human T cell growth factor and \u03b3\u2010interferon mRNA","volume":"132","author":"Arya S. 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