{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:27:32Z","timestamp":1770992852065,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6058,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1989,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have examined the influence of cyclosporin A (CsA), administered together with the polyamine antimetabolite, a\u2010difluoromethylornithine (DFMO), on growth of the Roser acute T\u2010cell leukaemia in PVG rats and on growth of the EL4 lymphoma in C57BL\/6 mice. CsA or DFMO alone, administered from the time of tumour injection, markedly reduced numbers of circulating lymphoblasts in leukaemic rats, although survival was prolonged only in those animals given DFMO. Drug combination further reduced blood\u2010borne tumour cells, but had no additional effects on tumour growth within organs or on host survival, compared to that achieved with DFMO treatment alone. Neither CsA nor DFMO, administered from the time of tumour\u2010cell injection, nor both drugs in combination, affected peritoneal growth of the EL4 lymphoma or organ infiltration. Host survival was prolonged by DFMO. As anticipated, DFMO inhibited polyamine synthesis <jats:italic>in vivo<\/jats:italic>, but the observed anti\u2010tumour effect of CsA was not accompanied by an alteration in polyamine biosynthesis. By reducing polyamine synthesis, however, DFMO may enhance the vulnerability of those malignant T cells which are susceptible to the as yet unexplained selective inhibitory action of CsA <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910440622","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:51:19Z","timestamp":1171921879000},"page":"1069-1073","source":"Crossref","is-referenced-by-count":8,"title":["Influence of cyclosporin a and \u03b1\u2010difluoromethylornithine, an inhibitor of polyamine biosynthesis, on two rodent T\u2010cell cancers <i>in vivo<\/i>"],"prefix":"10.1002","volume":"44","author":[{"given":"L. M.","family":"Smart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Maclachlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1017","article-title":"Effects of the now anti\u2010lymphoeyte peplide Cyclosporin A in the mouse","volume":"32","author":"Borel J. F.","year":"1977","journal-title":"Immunology."},{"key":"e_1_2_1_3_1","unstructured":"Bowlin T. L. Rosenberger A. L. andMcKown B. J. \u03b1\u2010Difluoromethylornithine an inhibitor of polyamine biosynthesis augments CsA inhibition of cytolytic T lymphocyte induction. Clin. exp. Immunol. (1989) (In press)."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313027509094412"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198602000-00011"},{"key":"e_1_2_1_6_1","first-page":"65","article-title":"Cyclosporin A antileukaemic activity: mode of action on target cells","volume":"65","author":"Foa P.","year":"1986","journal-title":"Boll. Seroter. (Milan)."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.4.922"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1981.tb01123.x"},{"key":"e_1_2_1_9_1","first-page":"355","article-title":"Effect of cyclosporin A on human lymphocyte responsesin vitro","volume":"128","author":"Hess A. D.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800711019"},{"key":"e_1_2_1_11_1","first-page":"4035","article-title":"Effect of \u03b1\u2010difluoromethylornithine and 5\u2010fluorouracil on the proliferation of a human colon adenocarcinoma cell line","volume":"43","author":"Kingsnorth A. N.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710513"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01962813"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00476a050"},{"key":"e_1_2_1_16_1","first-page":"1087","article-title":"Effect of cyclosporin A and \u03b1\u2010difluoromethylomithine on the growth of hamster pancreatic cellsin vitro","volume":"77","author":"Saydjarj R.","year":"1986","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175295"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90137-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173644"},{"key":"e_1_2_1_20_1","first-page":"1961","article-title":"Effects of DL \u03b1 methylornithine on proliferation and polyamine content of 9L rat brain tumour cells","volume":"40","author":"Seidenfeld J.","year":"1980","journal-title":"Cancer Res."},{"issue":"3","key":"e_1_2_1_21_1","first-page":"900","article-title":"Cyclosporine A and acute T cell leukaemia in the rat","volume":"20","author":"Smart L. M.","year":"1988","journal-title":"Transplant. Proc"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410618"},{"key":"e_1_2_1_23_1","first-page":"291","article-title":"Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines","volume":"48","author":"Thomson A. W.","year":"1983","journal-title":"Immunology"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1182\/blood.V59.5.1103.1103","article-title":"Cyclosporin A is selectively cytotoxic to human leukaemic T cellsin vitro","volume":"59","author":"Totterman T. H.","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_25_1","first-page":"985","article-title":"A possible role for cyclosporins in cancer research","volume":"8","author":"Twentyman P. R.","year":"1988","journal-title":"Anticancer Res."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2190211"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2530223"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910440622","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910440622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:42:22Z","timestamp":1697942542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910440622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12,15]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,12,15]]}},"alternative-id":["10.1002\/ijc.2910440622"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910440622","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12,15]]}}}