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The cells cannot be cloned in semi\u2010solid agar or grown in nude mice despite numerous attempts. The karyotype of the cultured cells is highly abnormal with a large number of structural and numerical changes. Some chromosomes are dicentric and this feature has persisted in this culture. The cells express one of the small\u2010intestinal dipeptidases, amino\u2010peptidase N, but do not express dipeptidyl peptidase IV or the disaccharidases, sucrase isomaltase or maltase glucoamylase. The cells express high levels of EGF receptors and of messenger RNA for insulin\u2010like growth factor II.<\/jats:p>","DOI":"10.1002\/ijc.2910440627","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:51:19Z","timestamp":1171921879000},"page":"1100-1103","source":"Crossref","is-referenced-by-count":8,"title":["A new gastric carcinoma cell line (LIM1839) derived from a young caucasian male"],"prefix":"10.1002","volume":"44","author":[{"given":"Robert H.","family":"Whitehead","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Novak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn E.","family":"Lukeis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca E.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1703","article-title":"Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach","volume":"43","author":"Barranco S. 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