{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:56:38Z","timestamp":1783634198980,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5996,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that human colorectal carcinoma cell lines, RCM\u20101 and CoCM\u20101, synthesize alpha\u20101\u2010antitrypsin (\u03b1<jats:sub>1<\/jats:sub>\u2010AT) in culture. We have studied immunohistochemically the incidence of \u03b1<jats:sub>1<\/jats:sub>\u2010AT on histologic sections from paraffin\u2010embedded tissues of surgically resected colorectal carcinomas and their metastatic foci, polypectomized adenomas, and normal mucosae. \u03b1<jats:sub>1<\/jats:sub>\u2010AT was detected in 89 (61%) of 145 carcinomas (including 14 carcinomas in adenoma), and 12 (39%) of 31 adenomas. But only 2 (4%) of 55 normal colorectal mucosae were positive for \u03b1<jats:sub>1<\/jats:sub>\u2010AT. In metastatic tumor cells of colorectal carcinomas in lymph nodes and other organs, \u03b1<jats:sub>1<\/jats:sub>\u2010AT positivity was 60% and 82%, respectively. The incidence of \u03b1<jats:sub>1<\/jats:sub>\u2010AT was markedly higher in advanced adenocarcinomas than in early ones and more frequent in adenocarcinomas of right side (including transverse colon) than those of left side and rectum, regardless of their histological malignancy grades. In mucinous carcinomas the frequency was greater (8 of 9 cases) than in conventional adenocarcinomas.<\/jats:p><jats:p>Clinical follow\u2010up of the patients with colorectal carcinomas suggested that \u03b1<jats:sub>1<\/jats:sub>\u2010AT positivity in Dukes' stage A\/B tends to correlate with unfavorable prognosis irrespective of the grade of histologic differentiation of carcinoma, but there is no significant relation in Dukes' stage C\/D. Our findings suggest that \u03b1<jats:sub>1<\/jats:sub>\u2010AT in colorectal carcinoma is related to the invasive and metastatic capacity. It may thus serve as a biologic marker for prognosis of colorectal carcinomas at relatively early stages (Dukes' stage A\/B).<\/jats:p>","DOI":"10.1002\/ijc.2910450207","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:59:30Z","timestamp":1171922370000},"page":"244-250","source":"Crossref","is-referenced-by-count":58,"title":["Prognostic significance of alpha\u20101\u2010antitrypsin in early stage of colorectal carcinomas"],"prefix":"10.1002","volume":"45","author":[{"given":"Seiichiro","family":"Karashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riruke","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Koono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00628.x"},{"key":"e_1_2_1_2_1","first-page":"93","article-title":"Intracellular localization of human plasma proteins revealed by peroxidase\u2010labeled antibody method in human tumors transplanted in nude mice","volume":"28","author":"Akatsuka A.","year":"1979","journal-title":"J. electron Microsc."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890201)63:3<496::AID-CNCR2820630318>3.0.CO;2-K"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00694904"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/274589a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(82)90149-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880915)62:6<1188::AID-CNCR2820620624>3.0.CO;2-E"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040211"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90156-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700350303"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881101)62:9<1994::AID-CNCR2820620920>3.0.CO;2-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1982.tb02701.x"},{"key":"e_1_2_1_13_1","first-page":"108","article-title":"Functional alpha 1 protease inhibitor produced by a human hepatoma cell line","volume":"99","author":"Glasgow J. 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