{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:21:46Z","timestamp":1790853706355,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5996,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We and others have previously shown that <jats:italic>in vitro<\/jats:italic> conversion of Epstein\u2010Barr virus (EBV)\u2010negative Burkitt lymphoma (BL) cell lines with the immortalizing B95\u20108 strain of EBV results in a marked elevation in levels of <jats:italic>c\u2010fgr<\/jats:italic> proto\u2010oncogene mRNA. We now show, using a nuclear run\u2010off assay, that this induction results from an increase in the rate of transcription of the c\u2010<jats:italic>fgr<\/jats:italic> gene. We also show that BL cell lines freshly converted with the non\u2010immortalizing HR\u2010I strain of EBV do not accumulate higher levels of c\u2010<jats:italic>fgr<\/jats:italic> mRNA, suggesting that EBNA\u20102 and\/or LMP, the genes which are deleted in the HR\u2010I strain, may be involved in the pathway which leads to changes in c\u2010<jats:italic>fgr<\/jats:italic> gene expression. In order to assess the generality of a role for the c\u2010<jats:italic>fgr<\/jats:italic> gene in the response of B\u2010lymphocytes to EBV\u2010infection, which is controversial, we have analysed c\u2010<jats:italic>fgr<\/jats:italic> expression in 6 freshly immortalized cell lines established by EBV (B95\u20108) infection of B\u2010lymphocytes from the peripheral blood of normal adults and of adults with rheumatoid arthritis, from cord blood, and from foetal liver. All 6 cell lines expressed c\u2010<jats:italic>fgr<\/jats:italic> mRNA at elevated levels compared to EBV\u2010negative BL cell lines.<\/jats:p>","DOI":"10.1002\/ijc.2910450222","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:59:30Z","timestamp":1171922370000},"page":"342-346","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of C\u2010<i>FGR<\/i> proto\u2010oncogene expression in epstein\u2010barr virus infected B\u2010cell lines"],"prefix":"10.1002","volume":"45","author":[{"given":"Mukesh","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally J.","family":"Leevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Brickell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.294"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.22.8060"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/319238a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.59.2.453-462.1986"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1242\/dev.103.1.111","article-title":"In situ hybridization reveals differential spatial localization of mRNAs for type I and type II collagen in the chick limb bud","volume":"103","author":"Devlin C. 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J.","year":"1988","journal-title":"J. Virol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.296"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.9.2762"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1128\/jvi.63.4.1531-1539.1989","article-title":"Influences of Burkitt's lymphoma and primary B cells on latent gene expression by the non\u2010immortalizing P3J\u2010HR\u20101 strain of Epstein\u2010Barr virus","volume":"63","author":"Rooney C.","year":"1989","journal-title":"J. Virol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370307"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.7.2983"},{"key":"e_1_2_1_22_1","first-page":"1043","article-title":"Regulation of c\u2010fgr proto\u2010oncogene expression in Burkitt's lymphoma cells: effect of interferon treatment and relationship to EBV status and c\u2010myc mRNA levels","volume":"4","author":"Sharp N.","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90165-7"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/j.1460-2075.1987.tb02412.x","article-title":"The activation antigen BLAST\u20102, when shed, is an autocrine BCGF for normal and transformed B\u2010cells","volume":"6","author":"Swendeman S.","year":"1987","journal-title":"EMBO J."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/304172a0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.10.3452"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90256-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.62.11.4173-4184.1988"},{"key":"e_1_2_1_29_1","first-page":"183","volume-title":"Advances in viral oncology","author":"Zeuthen J.","year":"1983"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910450222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910450222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:01:38Z","timestamp":1697990498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910450222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2,15]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2,15]]}},"alternative-id":["10.1002\/ijc.2910450222"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910450222","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2,15]]}}}