{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:15:56Z","timestamp":1759580156488},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5968,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A human Burkitt lymphoma (Daudi) has been grown in the mutant mouse called C.B\u201017 SCID. Twenty\u2010eight days after s.c. injection of Daudi cells, a palpable tumor grew only at the site of injection in all injected mice. In contrast, after intravenous (i.v.) or intraperitoneal (i.p.) injection, macroscopic, disseminated tumors developed. Following i.v. inoculation, tumors grew in the lungs, kidneys, ovaries and adipose tissue, and microscopic tumor infiltrates were observed in the spleen, bone marrow, spinal column and femur, whereas after i.p. injection, the tumors were localized in the abdomen, liver, spieen, ovaries and muscular tunics of the gut, but did not disseminate into the lung or bone marrow. The growth pattern and phenotype of the Daudi cells were similar whether the inoculated tumor cells were derived from the <jats:italic>in vitro<\/jats:italic> cell line or from <jats:italic>in vivo<\/jats:italic> passaged tumors. The survival time of the tumor\u2010bearing animals was dependent on the dose of i.v.\u2010administered Daudi cells; as few as 100 cells caused death. All mice injected i.v. showed paresis or paralysis of the hind legs just prior to death. This was associated with the presence of neoplastic nodules within the spinal canal. Two surface antigens on Daudi cells (CD19 and CD22) were stably expressed in all the neoplastic lesions. Radiolabelled anti\u2010CD22 antibodies localized in organs infiltrated with tumor, but did not penetrate primary s.c. tumors.<\/jats:p><jats:p>This model of disseminated vs. solid tumor should prove useful for evaluating the efficacy of different types and doses of therapeutic antibodies, immunoconjugates and immunotoxins prepared from anti\u2010human B\u2010cell antibodies.<\/jats:p>","DOI":"10.1002\/ijc.2910450318","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:58:48Z","timestamp":1171922328000},"page":"481-485","source":"Crossref","is-referenced-by-count":66,"title":["Disseminated or localized growth of a human B\u2010cell tumor (Daudi) in scid mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Maria\u2010Ana","family":"Ghetie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan W.","family":"Uhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen S.","family":"Vitetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/301527a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4049\/jimmunol.134.3.1524","article-title":"Human B\u2010cell development. 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