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Even at a dose as low as I mg\/kg\/day, PMEA effected a significant delay in tumor formation. When evaluated in parallel with PMEA, 3\u2032\u2010azido\u20102\u2032,3\u2032\u2010dideoxythymidine (AZT) conferred a comparable tumor\u2010inhibitory effect at a 5\u2010 to 10\u2010fold higher dose than PMEA. Prolonged treatment of MSV\u2010infected mice with PMEA resulted in long\u2010term survivors without apparent signs of tumor development. In view of the propensity of HIV to spread to the central nervous system (CNS), the marked activity shown by PMEA against experimental retrovirus infection of the brain in mice points to its potential in the treatment of AIDS and other retrovirus infections of the CNS.<\/jats:p>","DOI":"10.1002\/ijc.2910450319","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:58:48Z","timestamp":1171922328000},"page":"486-489","source":"Crossref","is-referenced-by-count":23,"title":["Inhibitory effects of 9\u2010(2\u2010Phosphonylmethoxyethyl)adenine and 3\u2032\u2010azido\u20102\u2032,3\u2032\u2010dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus"],"prefix":"10.1002","volume":"45","author":[{"given":"Jan","family":"Balzarini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halina","family":"Sobis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieve","family":"Naesens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Vandeputte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"De Clercq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.332"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(75)90259-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.2.185"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-383"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6200936"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc19872801"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2.14.2846395"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6328660"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1987.49"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198711000-00001"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.7.1025"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6200935"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.3.630"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91968-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92808-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230722"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910450319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910450319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:43:39Z","timestamp":1698025419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910450319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3,15]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3,15]]}},"alternative-id":["10.1002\/ijc.2910450319"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910450319","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3,15]]}}}