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Its principal characteristics are: strong positivity with monoclonal antibodies (MAbs) to CD25, CD30, CD45R, KiM7, EMA, HLA CI I and II; constant presence of acid phosphatase, ANAE, \u03b1\u2010anti\u2010trypsin, \u03b1\u2010anti\u2010chymotrypsin and NBT reduc\u2010tase activity; rearrangement of the immunoglobulin heavychain gene (JH) and a germ\u2010line configuration of the T\u2010chain gene; and finally a translocation between chromosomes 5\u20136 with a breakpoint in 5q35. The DEL cell line is appropriate for studying the role of the 5q localized <jats:italic>c\u2010fms<\/jats:italic> oncogene and of the genes of the mononuclear phagocyte growth factor (CSFI) and of their receptors in the dynamics and etiology of malignant hemopathies associated with a 5q35 breakpoint.<\/jats:p>","DOI":"10.1002\/ijc.2910450329","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:58:48Z","timestamp":1171922328000},"page":"546-553","source":"Crossref","is-referenced-by-count":19,"title":["Del cell line: A \u201cmalignant histiocytosis\u201d CD30 + T(5;6)(Q35;P21) cell line"],"prefix":"10.1002","volume":"45","author":[{"given":"Sylvette","family":"Barbey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Gogusev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e9ne","family":"Mouly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Le Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wandy","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle","family":"Soulie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Nezelof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"187","article-title":"Human macrophages can express the Hodgkin's cell\u2010associated antigen Ki\u20101 (CD30)","volume":"134","author":"Andreesen R.","year":"1989","journal-title":"Amer. 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