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In order to examine the role played by activation of c\u2010<jats:italic>myc<\/jats:italic> in determining the eBL phenotype, we have introduced into EBV\u2010immortalized lymphoblastoid cells (LCL) plasmids which permit constitutive expression of c\u2010<jats:italic>myc<\/jats:italic>. The resulting cells show a reduced serum dependence, reduced homotypic cell aggregation, and changes in surface characteristics. In particular, levels of the cell adhesion molecule, LFA\u20101, are greatly reduced. However, the cells continue to express all the EBV latent antigens associated with the LCL phenotype and they remain nontumorigenic. These results suggest that, whilst constitutive expression of c\u2010<jats:italic>myc<\/jats:italic> may contribute to the malignant phenotype, it is insufficient to induce tumorigenicity.<\/jats:p>","DOI":"10.1002\/ijc.2910450332","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:58:48Z","timestamp":1171922328000},"page":"566-571","source":"Crossref","is-referenced-by-count":22,"title":["Deregulated c\u2010<i>myc<\/i> expression in epstein\u2010barr\u2010virus\u2010immortalized b\u2010cells induces altered growth properties and surface phenotype but not tumorigenicity"],"prefix":"10.1002","volume":"45","author":[{"given":"Neil A.","family":"Hotchin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Allday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy H.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.1.67"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.10.4353"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-7-1755"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90386-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92924-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60200-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-01082-7.50075-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60436-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1128\/jvi.61.12.3870-3878.1987","article-title":"Monoclonal and polyclonal antibodies against Epstein\u2010Barr virus nuclear antigen 5 (EBNA\u20105) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines","volume":"61","author":"Finke J.","year":"1987","journal-title":"J. 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