{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:12Z","timestamp":1762160592481,"version":"3.33.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5938,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ninety\u2010seven Japanese patients with so\u2010called primary non\u2010Hodgkin's lymphoma of the central nervous system (CNS\u2010NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1. The most frequent past histories were acute appendicitis (appendectomy), head injury, uveitis or iritis, and gastritis or gastric ulcer. These patients presented with symptoms suggesting an expanding intracranial lesion with no signs of extracranial lymphomatous disease. Combined computed tomographic scans, angiography, and findings at surgery or autopsy showed that the cerebrum was the commonest site of involvement, 87% of all cases, with the frontal to temporal region being the most commonly involved. Histologically, the diffuse large\u2010cell type was most frequent and 26% of lymphomas were of high\u2010grade malignancy as defined by the Working Formulation. The reported frequency of high\u2010grade CNS\u2010NHLs in AIDS patients in the United States is much higher (over 60%). Immunohistochemistry on paraffin\u2010embedded sections revealed a B\u2010cell nature of the present series of tumors. In 16% of the cases, large numbers of small lymphoid cells with a positive reaction predominantly for anti\u2010T lymphocyte antibodies surrounded the tumors or aggregated around the capillaries. The tumors which were infiltrated by small lymphoid cells showed more favorable prognosis than those which were not, suggesting a host reaction to tumor growth in these patients.<\/jats:p>","DOI":"10.1002\/ijc.2910450410","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:58:12Z","timestamp":1171922292000},"page":"632-636","source":"Crossref","is-referenced-by-count":15,"title":["Malignant lymphoma of the central nervous system in Japan: Histologic and immunohistologic studies"],"prefix":"10.1002","volume":"45","author":[{"given":"Katsuyuki","family":"Aozasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Yamabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuko","family":"Shima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kirimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsumi","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kurata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860701)58:1<100::AID-CNCR2820580118>3.0.CO;2-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860501)57:9<1762::AID-CNCR2820570909>3.0.CO;2-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(85)90042-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870901)60:5<969::AID-CNCR2820600509>3.0.CO;2-Z"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox D. R.","year":"1972","journal-title":"J. roy statist. Soc. (Ser. B)."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881201)62:11<2461::AID-CNCR2820621135>3.0.CO;2-M"},{"key":"e_1_2_1_8_1","first-page":"121","article-title":"Immuno\u2010surveillance and cancer: epidemiologic observations","volume":"47","author":"Fraumeni J. F.","year":"1977","journal-title":"Nat. Cancer Inst. Monogr."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860901)58:5<1106::AID-CNCR2820580521>3.0.CO;2-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:4<1293::AID-CNCR2820340441>3.0.CO;2-P"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503073121001"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871015)60:8<1771::AID-CNCR2820600817>3.0.CO;2-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_15_1","first-page":"1085","article-title":"Chronic thyroiditis as a risk factor of B\u2010cell lymphoma in the thyroid gland","volume":"76","author":"Kato I.","year":"1985","journal-title":"Jap. J. Cancer Res."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820301)49:5<939::AID-CNCR2820490518>3.0.CO;2-1"},{"key":"e_1_2_1_17_1","first-page":"1","article-title":"Monoclonal antibodies marking T lymphocytes in paraffinembedded tissue","volume":"127","author":"Linder J.","year":"1987","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880815)62:4<735::AID-CNCR2820620416>3.0.CO;2-E"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880701)62:1<203::AID-CNCR2820620130>3.0.CO;2-6"},{"key":"e_1_2_1_20_1","first-page":"105","article-title":"Malignant lymphomas: a conceptual understanding of morphologic diversity","volume":"94","author":"Mann R. B.","year":"1979","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_21_1","first-page":"497","article-title":"Immunohistochemical analysis of human lymphomas with monoclonal antibodies to B cell and la antigens reactive in paraffin sections","volume":"52","author":"Marder R. J.","year":"1985","journal-title":"Lab. Invest."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861015)58:8<1609::AID-CNCR2820580805>3.0.CO;2-7"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41310-3"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_1_25_1","first-page":"418","article-title":"Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin\u2010embedded tissue sections","volume":"127","author":"Poppema S.","year":"1987","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91384-5"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<232::AID-CNCR2820380135>3.0.CO;2-4"},{"key":"e_1_2_1_28_1","first-page":"2122","article-title":"The non\u2010Hodgkin's lymphoma pathologic classification project. National Cancer Institute sponsored study of classifications of non\u2010Hodgkin's lymphomas: summary and description of a Working Formulation","volume":"49","author":"WORKING FORMULATION","year":"1982","journal-title":"Cancer"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408303110904"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910450410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910450410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T22:12:08Z","timestamp":1736806328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910450410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,15]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4,15]]}},"alternative-id":["10.1002\/ijc.2910450410"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910450410","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"type":"print","value":"0020-7136"},{"type":"electronic","value":"1097-0215"}],"subject":[],"published":{"date-parts":[[1990,4,15]]}}}