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For this purpose, a highly leukemic cell line NQ22, derived from a MCF 247 murine leukemia virus (MuLV)\u2010induced murine T\u2010cell lymphoma, was established, and its preliminary characterization is described. The NQ22 cell line is easily transplantable subcutaneously (s.c.) into syngeneic AKR mice exhibiting early peripheral blood invasion and widespread dissemination with a leukemic pattern of infiltration. Such peculiar <jats:italic>in vivo<\/jats:italic> behavior is a stable phenotypic feature, probably determined genetically. Biological and differentiation characteristics of the NQ22 cell line were analyzed and compared to those of other non\u2010leukemic T\u2010lymphoma lines. In addition, no evidence of possible involvement of plasminogen activator (PA) enzymes and of their inhibitors (PA1) in the spreading ability of NQ22 cells was observed.<\/jats:p>","DOI":"10.1002\/ijc.2910450525","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:55:30Z","timestamp":1171922130000},"page":"928-934","source":"Crossref","is-referenced-by-count":5,"title":["Establishment and characterization of a leukemic murine cell line derived from MCF 247 MuLV\u2010induced T\u2010cell lymphoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Riccardo","family":"Dolcetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Barlati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Maestro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvia","family":"Sonego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giordana","family":"Feriotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Bellotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Boiocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/030089168407000601","article-title":"Integration and expression of MCF\u201013 provirus in MCF 13\u2010induced lymphomas","volume":"70","author":"Boiocchi M.","year":"1984","journal-title":"Tumori"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.5.1654"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/312031a0"},{"key":"e_1_2_1_5_1","first-page":"5748","article-title":"Relationship between circulating plasminogen activators and tumor development in mice","volume":"46","author":"Colombi M.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60028-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340522"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(88)90223-4"},{"key":"e_1_2_1_9_1","first-page":"1009","article-title":"N\u2010myc activation by proviral insertion in MCF 247\u2010induced murine T\u2010cell lymphomas","volume":"4","author":"Dolcetti R.","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1182\/blood.V54.6.1417.1417","article-title":"Incidence and patterns of bone marrow and blood involvement by lymphoma in relationship to the Lukes\u2010Collins classification","volume":"54","author":"Foucar R. 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