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Whereas transplant and B\u2010cell lymphomas from cottontop tamarins appear to express the full range of antigens found in LCLs, we and others have found that in Burkitt's lymphomas (BL) and a nasopharyngeal carcinoma (NPC) isolate, EBNA expression is restricted to EBNA\u20101. (In NPC, but not in BL, LMP may also be expressed.) In order to ask what restricts the expression of EBNA 2\u20136 in NPC and BL cells it seemed reasonable to consider the possibility that the DNA sequences normally regulating expression of these antigens could be chemically modified. In this analysis, a tight inverse correlation between methylation of CpG dinucleotides in the 5\u2032 flanking region of the EBNA\u20102 gene and the expression of EBNAs 2\u20136 has been revealed. In the NPC tumour, CpG methylation within the gene is also observed, as is specific methylation over the EBNA\u20101 region I and II binding sites (in oriP). The significance of these observations is considered.<\/jats:p>","DOI":"10.1002\/ijc.2910450623","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:54:30Z","timestamp":1171922070000},"page":"1125-1130","source":"Crossref","is-referenced-by-count":22,"title":["CpG methylation of viral DNA in EBV\u2010associated tumours"],"prefix":"10.1002","volume":"45","author":[{"given":"M. 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