{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:10:45Z","timestamp":1698041445131},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5846,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor cell variants were established <jats:italic>in vitro<\/jats:italic> by treating a metastatic variant of murine colon adenocarcinoma 26 (P\u201026\u2010select) in serum\u2010free RPMI 1640 medium for 6 to 10 weeks. Five tumor cell lines were established from independent cultures and designated PS\u2010I to PS\u20105. The PS cells showed higher growth potential <jats:italic>in vitro<\/jats:italic> under serum\u2010free or low\u2010serum conditions than the parental P\u201026\u2010select. In comparison to P\u201026\u2010select, the PS cell lines possessed enhanced lung\u2010colonizing ability after i. v. inoculation and metastasized spontaneously to the lung following s. c. inoculation into the flank or the right fore\u2010footpads of BALB\/c mice. Metastatic nodules were also observed in the liver. Spleens and livers of the tumor\u2010bearing mice were enlarged mainly as a result of hematopoiesis, suggesting the production of CSF\u2010like substance(s) by the tumor cells. The PS cells secreted increased amounts of putative autocrine growth factor(s) and CSF\u2010like substance(s) <jats:italic>in vitro.<\/jats:italic> These characteristics might be related to the <jats:italic>in vivo<\/jats:italic> metastatic ability of the PS cells.<\/jats:p>","DOI":"10.1002\/ijc.2910460122","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:53:54Z","timestamp":1171922034000},"page":"118-124","source":"Crossref","is-referenced-by-count":0,"title":["Establishment of highly metastatic variants of murine colon adenocarcinoma 26 under serum\u2010free conditions"],"prefix":"10.1002","volume":"46","author":[{"given":"Yoshikazu","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Oh\u2010hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Heike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Nakatsuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tsuruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90331-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/337471a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.5.318"},{"key":"e_1_2_1_5_1","first-page":"4590","article-title":"Transforming growth factor \u03b1 and \u03b2 expression in human colon cancer lines: implications for an autocrine model","volume":"47","author":"Coffey R. 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