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Hyaluronan was significantly increased in sera of metastatic patients compared to sera of non\u2010metastatic patients (<jats:italic>p<\/jats:italic> &lt; 0.0001) and also in sera of non\u2010metastatic patients when compared to control sera (<jats:italic>p<\/jats:italic> &lt; 0.01). The difference was not related to the number of metastatic sites involved. Three months after starting cytotoxic chemotherapy in metastatic patients, lower HA concentrations were observed in patients responding to chemotherapy. The initial level of serum HA had no predictive value concerning response to chemotherapy.<\/jats:p>","DOI":"10.1002\/ijc.2910460309","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:13Z","timestamp":1171923373000},"page":"388-390","source":"Crossref","is-referenced-by-count":69,"title":["Serum hyaluronan (hyaluronic acid) in breast cancer patients"],"prefix":"10.1002","volume":"46","author":[{"given":"Bertrand","family":"Delpech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Chevallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Duval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Maingonnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bastit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Asselain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(85)90231-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.283"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890701)64:1<68::AID-CNCR2820640112>3.0.CO;2-I"},{"key":"e_1_2_1_5_1","first-page":"3499","article-title":"Hyaluronic acid\u2010stimulating activity in sera from the bovine fetus and from breast cancer patients","volume":"49","author":"Decker M.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90613-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.2.83"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050420"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060310"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870615)59:12<2104::AID-CNCR2820591224>3.0.CO;2-I"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184331"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2580919"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470513774.ch10"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(89)90027-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.6.445"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"e_1_2_1_17_1","first-page":"993","article-title":"The mucopolysaccharides in the normal and diseased breast","volume":"34","author":"Ozello L.","year":"1958","journal-title":"Amer. 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