{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:54:55Z","timestamp":1774479295101,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5784,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the possible involvement of parathyroid hormone\u2010related protein (PTHrP) in 2 cases of metastatic pancreatic neuro\u2010endocrine tumors associated with severe hypercaicemia. Both patients displayed biochemical alterations in renal tubular reabsorption of calcium and phosphate, as well as in urinary cAMP excretion, similar to those encountered in primary hyperparathyroidism, although plasma levels of parathyroid hormone were within the normal range. Tumor protein extracts stimulated cAMP production, which was inhibited by the PTH\u2010antagonist (8,18 Nle, 34 Tyr)bPTH\u2010(3\u201034)amide, in the PTH\u2010responsive osteoblastic cell line UMR\u2010106. Northern blot analysis of tumor extracts revealed the presence of PTHrP mRNA transcripts, while PTH mRNA was undetectable. In contrast, neither PTHrP mRNA(s) nor cAMP\u2010stimulating activity was detectable in other neuroendocrine tumors not accompanied by hypercaicemia. These results demonstrate that certain pancreatic neuroendocrine tumors associated with hypercaicemia can synthesize and release PTHrP.<\/jats:p>","DOI":"10.1002\/ijc.2910460311","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:13Z","timestamp":1171923373000},"page":"394-398","source":"Crossref","is-referenced-by-count":26,"title":["Parathyroid hormone\u2010related protein and hypercalcemia in pancreatic neuro\u2010endocrine tumors"],"prefix":"10.1002","volume":"46","author":[{"given":"R.","family":"Rizzoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"Sappino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. \u2010P.","family":"Bonjour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.4049\/jimmunol.139.4.1336","article-title":"Constitutive and induced expression of the individual HLA\u2010DR and chain loci in different cell types","volume":"39","author":"Berdoz J.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90280-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(88)90001-4"},{"key":"e_1_2_1_5_1","first-page":"509","article-title":"Diphosphonate therapy in hypercalcemia of malignancy and tumoral osteolysis","volume":"5","author":"Bonjour J. 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