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After 6 days in culture, the lytic properties of the LAK cells were analyzed in the <jats:sup>51<\/jats:sup>Cr\u2010release assay by utilizing a target panel of 6 paired lines consisting of an Epstein\u2010Barr virus (EBV)\u2010positive Burkitt's lymphoma (BL) cell line and an EBV\u2010transformed lymphoblastoid cell line (LCL) from the same donor, the Raji BL line and the natural killer (NK) cell\u2010sensitive K562 line. The patterns of lysis showed that the LAK cells discriminated between two categories of BL cell lines. Group l\/ll BL tumor cells which expressed the common acute lymphoblastic leukemia antigen (CALLA), the BL\u2010associated glycolipid antigen (BLA) and phenotypically resembled biopsy cells were strongly lysed whereas group III BL cells which had assumed an LCL\u2010like phenotype during culture and lacked the CALLA and BLA surface markers were only poorly lysed. The LCL targets were generally resistant to lysis but the K562 cell line was particularly sensitive. The outcome of cell depletion and monoclonal antibody (MAb) studies indicated that the LAK cell populations were phenotypically and functionally heterogeneous and consisted of at least 2 subpopulations of effector cells; a tumor\u2010specific component and an NK\u2010cell\u2010mediated component.<\/jats:p>","DOI":"10.1002\/ijc.2910460312","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:13Z","timestamp":1171923373000},"page":"399-404","source":"Crossref","is-referenced-by-count":6,"title":["Lymphokine\u2010activated killer (lak) cells discriminate between epstein\u2010barr virus (ebv)\u2010positive burkitt's lymphoma cells"],"prefix":"10.1002","volume":"46","author":[{"given":"Ihor S.","family":"Misko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Sculley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelcey J.","family":"Burman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.4049\/jimmunol.142.10.3692","article-title":"Cytotoxic T lymphocyte clones from peripheral blood and from tumor site detect intratumor heterogeneity of melanoma cells","volume":"142","author":"Anichini A.","year":"1989","journal-title":"J. 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