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After i. v. injection of the 2 tumor lines there was no significant difference either in the number of lung colonies or in the frequency and tissue distribution of extrapulmonary tumor deposits. These findings suggest that the selection in the spleen\u2010liver system did not result in an overall increase in the metastatic potential of the melanoma cells, but rather that it represented an organ\u2010preferential selection. The HT168\u2010MI cells did not acquire an increased growth rate <jats:italic>in vitro<\/jats:italic> or <jats:italic>in vivo<\/jats:italic>, suggesting that other phenotypic alterations are responsible for the enhanced metastatic capacity. The 2 tumor lines were characterized by similar expression of HLA\u2010A, B, C, transferrin receptor and melanoma\u2010associated proteoglycan antigen. HT168 contained more NGF receptor, while HLA\u2010DR appeared only on HT 168\u2010MI cells. This human metastasis model could be useful in studying the mechanisms of liver metastasis formation, as well as in revealing possible new targets of antimetastatic therapy.<\/jats:p>","DOI":"10.1002\/ijc.2910460322","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:16:13Z","timestamp":1171923373000},"page":"456-461","source":"Crossref","is-referenced-by-count":34,"title":["Selection and characterization of human melanoma lines with different liver\u2010colonizing capacity"],"prefix":"10.1002","volume":"46","author":[{"given":"A.","family":"Lad\u00e1nyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tim\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Paku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lapis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"253","article-title":"Metastasis distribution in malignant melanoma","volume":"7","author":"Akslen L. 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