{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:59:33Z","timestamp":1790967573662,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5754,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> infection of EBV\u2010negative lymphoma cell lines with immortalizing strains of Epstein\u2010Barr virus induces the cellsurface expression of B\u2010cell markers, such as the EBV receptor\/CR2 (CD21) and the CD23 antigen. The non\u2010immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antigen 2 (EBNA2) gene, fails to induce any such expression. We show here that the EBV\u2010mediated up\u2010regulation of cell\u2010surface expression of these molecules is associated with an increased level of the specific steady\u2010state RNA corresponding to these 2 genes. These results suggest that the role of EBNA2 in B\u2010cell growth and immortalization may be related to its role in transactivation of cellular genes. In order to identify other cellular genes whose expression may be modulated by EBV, we analyzed the level of transcription of a set of genes possibly involved in Burkitt's lymphoma pathogenesis. The level of the c\u2010<jats:italic>myc<\/jats:italic> oncogene transcript was not significantly affected by <jats:italic>in vitro<\/jats:italic> EBV infection. The c\u2010<jats:italic>fgr<\/jats:italic> oncogene, thought to be specifically activated in EBV\u2010infected cells, was found to be expressed in some EBV\u2010negative lymphoma cells and also to be activated by both non\u2010immortalizing and immortalizing strains of EBV. The expression of vimentin, the major 56\u2010kDa polypeptide of mesenchymal cell intermediate filaments, was altered by all EBV isolates, in either a negative or a positive way, depending on the cell line. Expression of lymphocyte\u2010function\u2010associated antigens, LFA\u2010I \u03b1\/\u03b2 (CDI la\/18) and LFA\u20103 (CD58), involved in intercellular adhesion and the T\u2010cytotoxic pathway, were differentially regulated by EBV; a crucial observation was the activation by immortalizing EBV isolates of LFA\u20101 \u03b2 chain (CD18) and of LFA\u20103 (CD58). The EBV\u2010 and possibly EBNA2\u2010associated modulation of cellular genes, such as CR2 (CD21), CD23 and LFAs, probably represents key events for EBV\u2010induced B\u2010cell proliferation, and also for <jats:italic>in vivo<\/jats:italic> immune control of EBV\u2010infected B cells.<\/jats:p>","DOI":"10.1002\/ijc.2910460418","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:14:07Z","timestamp":1171923247000},"page":"658-663","source":"Crossref","is-referenced-by-count":36,"title":["Modulation of cellular gene expression in B lymphoma cells following <i>in vitro<\/i> infection by Epstein\u2010Barr virus (EBV)"],"prefix":"10.1002","volume":"46","author":[{"given":"Alain","family":"Calender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Billaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert M.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91214-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/blood.V75.9.1827.1827","article-title":"Low expression of lymphocytes function\u2010associated antigen (LFA)\u20101 and LFA\u20103 adhesion molecules is a common trait in Burkitt's lymphoma associated with and not associated with Epstein\u2010Barr virus","volume":"75","author":"Billaud M.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1128\/jvi.63.9.4079-4084.1989","article-title":"Epstein\u2010Barr virus latent infection membrane protein increases vimentin expression in human B\u2010cell lines","volume":"63","author":"Birkenbach M.","year":"1989","journal-title":"J. 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