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In addition, other biopsies showed a loss in expression of particular allelic products: 23% for HLA\u2010A2; 17% for HLA\u2010A3; 23% for HLA\u2010Bw4 and 19% for HLA\u2010Bw6. Three biopsies showed changes at 2 alleles, 2 of which were at both HLA\u2010A and \u2010B loci. Down\u2010regulation of class\u2010I expression may be virally mediated and HPV DNA is frequently found in cervical carcinomas. However, there appeared to be no direct correlation between the detection of HPV 16 or 18 DNA in these tumours and changes in HLA expression. There was also no correlation with the expression of the oncofoetal antigen 5T4. Our results show that a significant proportion (at least 30%) of the cervical carcinomas showed some alteration in MHC class\u2010I expression. Such changes may allow tumours to evade immune surveillance with more rapid progression. There was, however, no correlation with tumour type, degree of differentiation or stage of disease at presentation.<\/jats:p>","DOI":"10.1002\/ijc.2910460614","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:09:48Z","timestamp":1171922988000},"page":"1029-1034","source":"Crossref","is-referenced-by-count":141,"title":["Loss of MHC class\u2010I expression in cervical carcinomas"],"prefix":"10.1002","volume":"46","author":[{"given":"Mary E.","family":"Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(88)90225-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03003176","article-title":"Presence of HPV 16 and 18 in genital warts and cervical neoplasias","volume":"5","author":"Battista C.","year":"1988","journal-title":"Med. 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