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We found that heparanase is produced and released by 3 out of 4 pre\u2010B lymphomas and by 4 B lymphomas examined. In contrast, 5 plasmacytomas and resting normal B lymphocytes, expressed little, if any, heparanase activity. Treatment with LPS resulted in high expression of the enzyme by normal B\u2010lymphocytes, but there was no effect on the constitutive production of heparanase by myeloma or B\u2010lymphoma cells. Our results indicate that heparanase is produced by B cells during discrete stages of their maturation. We suggest that heparanase may play a role in B\u2010cell migration by enabling pre\u2010B and B lymphocytes to leave the bone\u2010marrow compartment and recirculate among peripheral lymphoid organs.<\/jats:p>","DOI":"10.1002\/ijc.2910470117","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:08:06Z","timestamp":1171922886000},"page":"92-98","source":"Crossref","is-referenced-by-count":25,"title":["Production of heparanase by normal and neoplastic murine B\u2010lymphocytes"],"prefix":"10.1002","volume":"47","author":[{"given":"Reuven","family":"Laskov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka\u2010Ishai","family":"Michaeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hava","family":"Sharir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eitan","family":"Yefenof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Vlodavsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01955.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1182\/blood.V70.2.551.551","article-title":"Inhibition of heparanase\u2010mediated degradation of extracellular matrix heparan sulfate by modified and non\u2010anticoagulant heparin species","volume":"70","author":"Bar\u2010Ner M.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041280223"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00430a047"},{"key":"e_1_2_1_6_1","first-page":"6590","article-title":"Clonal analysis of radiation\u2010leukemia\u2010virus(RadL V)\u2010induced leukemic and preleukemic cells","volume":"47","author":"Ben David Y.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4049\/jimmunol.133.2.744","article-title":"A unique series of lymphomas related to the lyl+ lineage of B\u2010lymphocyte differentiation","volume":"133","author":"Davidson W. 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