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The heterochromatic region was located pericentromerically, adjacent at one end to the NOR region of chromosome 15, and at the other to an unclassifiable chromosomal piece. We established that the C\u2010positive block in the marker chromosome originated from Y heterochromatin by high\u2010stringency in situ hybridization with a DNA probe for the 2.1 Hae III Y\u2010specific repeat. Loss of the Y chromosome in tumors has been considered to be a secondary event associated with malignant evolution. It is significant that Me 1402 cells, which are highly malignant, lack the Y chromosome, but retain its heterochromatic portion in the rearranged m3 chromosome.<\/jats:p>","DOI":"10.1002\/ijc.2910470127","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:08:06Z","timestamp":1171922886000},"page":"154-157","source":"Crossref","is-referenced-by-count":4,"title":["Loss of Y chromosome with retention of Y heterochromatin in a marker chromosome from a human melanoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Luisa","family":"Doneda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Larizza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90042-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1973.22"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295378"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90093-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90181-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90233-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333470"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90008-2"},{"key":"e_1_2_1_10_1","first-page":"433","article-title":"In situ hybridization of interstitial C\u2010heterochromatin in marker chromosomes of two human melanomas","volume":"49","author":"Doneda L.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90028-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90224-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90275-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90018-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01753674"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132132"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840701)54:1<48::AID-CNCR2820540112>3.0.CO;2-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90106-3"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197210)30:4<889::AID-CNCR2820300405>3.0.CO;2-1"},{"key":"e_1_2_1_20_1","first-page":"317","article-title":"Tumorigenicity and dissemination of primary and metastatic human melanomas implanted into different sites in athymic nude mice","volume":"8","author":"Rodolfo M.","year":"1988","journal-title":"Invas. 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