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Moderate to strong expression of GRP mRNA was detected in 5 breast carcinomas by Northern blot analysis with a pre\u2010pro\u2010GRP probe; 4 other cases were weakly reactive. Two of these cases also gave a specific immunocytochemical reaction for GRP, controlled with absorption experiments. Correlation with NE differentiation [as shown by chromogranins (Cg) and\/or NSE and\/or Grimelius positivity] was low, since only one case of breast carcinoma co\u2010expressed GRP and Cg mRNAs. Breast cancer cell lines and a rat carcinoma gave negative results. GRP production in breast cancer did not appear to bear prognostic implications, but longer follow\u2010up periods are needed to confirm these data. As shown in small\u2010cell lung cancer, GRP might be involved in autocrine growth control mechanisms of a group of breast carcinomas.<\/jats:p>","DOI":"10.1002\/ijc.2910470310","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:05:43Z","timestamp":1171922743000},"page":"371-375","source":"Crossref","is-referenced-by-count":22,"title":["Expression of the gastrin\u2010releasing peptide gene in carcinomas of the breast"],"prefix":"10.1002","volume":"47","author":[{"given":"A.","family":"Pagani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Papotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sanfilippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bussolati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198704000-00002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197712000-00001"},{"key":"e_1_2_1_5_1","first-page":"709","article-title":"Autocrine growth factors in human small cell lung cancer","volume":"4","author":"Cuttitta F.","year":"1985","journal-title":"Cancer Surv."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(85)90004-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.7.2379"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.9.3240"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb16033.x"},{"key":"e_1_2_1_10_1","first-page":"243","article-title":"A silver nitrate stain for a2 cells in human pancreatic islets","volume":"73","author":"Grimelius L.","year":"1968","journal-title":"Acta Soc. med. 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