{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:47:21Z","timestamp":1698144441475},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5646,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 72 human leukemia\u2010lymphoma cell lines were studied for reactivity with the monoclonal antibody (MAb) A7, an anti\u2010human colon\u2010cancer\u2010cell\u2010associated antigen reagent, by indirect membrane immunofluorescence. Nine of the 72 cell lines expressed the antigen recognized by A7 MAb. Five of the 34 T\u2010cell lines, 2 of the 21 B\u2010cell lines, and 2 of the 3 non\u2010lymphoid\u2010non\u2010myeloid cell lines were reactive with A7 MAb. By means of SDS\u2010PAGE and immunoblotting, the antigens isolated from both colon cancer cell lines (WiDr, SW1 116 and LoVo) and leukemia cell lines (A3\/KAWAKAMI, H9, RPM1 8226 and SPI\u2010801) showed an identical MW of 42\u201043 kOa. The non\u2010glycosylated antigen recognized by A7 MAb, which was expressed on both the colon cancer line (SW1 116) and the leukemia line (H9) in the presence of tunicamycin, also showed an identical MW of 36 kDa. However, the quantity of the antigen in the leukemia cells was significantly lower than in the colon cancer cells. Although expression of this colon\u2010cancer\u2010associated antigen in the non\u2010colon cancer cells is real, the significant expression of this antigen in colon\u2010cancer cells makes it useful for clinical monitoring of colon cancer patients.<\/jats:p>","DOI":"10.1002\/ijc.2910470320","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:05:43Z","timestamp":1171922743000},"page":"426-430","source":"Crossref","is-referenced-by-count":1,"title":["Identification and characterization of a colon\u2010cancer\u2010associated antigen expressed on leukemia\u2010lymphoma cell lines"],"prefix":"10.1002","volume":"47","author":[{"given":"Y.","family":"Chimori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Minowada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(87)90164-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68857-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860201)57:3<433::AID-CNCR2820570305>3.0.CO;2-Q"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(75)90171-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/255714a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jnci\/77.3.599","article-title":"Gastrointestinal carcinoma\u2010associated antigen defined by a murine monoclonal antibody","volume":"77","author":"Chin J. 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