{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:57:13Z","timestamp":1774677433072,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5626,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For detailed comparison of human T\u2010cell leukemia virus type I (HTLV\u2010I) in adult T\u2010cell leukemia (ATL) and HTLV\u2010I\u2010associated myelopathy (HAM), the nucleotide sequences of parts of the long terminal repeat (LTR) and <jats:italic>env<\/jats:italic> regions of the HTLV\u2010I proviruses from 12 patients with HAM, 8 patients with ATL and one with both diseases were analyzed. About 340 bp of the LTR U3 region, about 4S0 bp of the 5\u2032 region and about 280 bp of the 3\u2032 region of <jats:italic>env<\/jats:italic> were sequenced directly in DNAs amplified by the polymerase chain reaction (PCR) with 2 or 3 sets of primers for each region. Nucleotide insertions, deletions or point mutations were observed at 50 positions in these regions of about 1,000 nucleotides length. None of these changes was specific to either HAM or ATL, and some changes were observed in proviruses from both cases of HAM and ATL. Moreover, the sequences of proviruses isolated from pairs of cell lines established from cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) of the 4 patients with HAM also had different sequences. These results indicate that the proviruses from HAM and ATL are indistinguishable in these sequenced regions, suggesting that these 2 diseases are caused by infection with genetically indistinguishable HTLV\u2010I. Therefore, the reason why these two distinct diseases, HAM and ATL, develop in HTLV\u2010I carriers may be based on a host factor(s) or some other factor(s) rather than variation in the virus itself.<\/jats:p>","DOI":"10.1002\/ijc.2910470403","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:04:44Z","timestamp":1171922684000},"page":"491-495","source":"Crossref","is-referenced-by-count":50,"title":["Sequence variations in ltr and <i>env<\/i> regions of HTLV\u2010I do not discriminate between the virus from patients with HTLV\u2010I\u2010associated myelopathy and adult T\u2010cell leukemia"],"prefix":"10.1002","volume":"47","author":[{"given":"Tomohiro","family":"Kinoshita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumi","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitada","family":"Shimotohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430227"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90081-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.19.6061"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420213"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(86)90278-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1988.tb01608.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5620"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/308467a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(80)65059-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_13_1","first-page":"219","article-title":"Type\u2010C\u2010virus\u2010producing cell lines derived from adult T\u2010cell leukemia","volume":"28","author":"Miyoshi I.","year":"1982","journal-title":"Gann Monogr."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210203"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6600519"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/jvi.60.3.910-919.1986","article-title":"Cas\u2010Br\u2010E murine leukemia virus: sequencing of the paralytogenic region of its genome and derivation of specific probes to study its origin and the structure of its recombinant genomes in leukemic tissues","volume":"60","author":"Rassart E.","year":"1986","journal-title":"J. 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