{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:02:00Z","timestamp":1761742920778},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5626,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between intracystic levels of epidermal growth factor (EGF) and those of dehydroepiandrosterone sulphate (DHEA\u2010S), \u0394\u20104\u2010androstenedione (\u0394\u20104\u2010A), 17\u2010\u03b2\u2010estradiol (17\u2010\u03b2\u2010E) and progesterone (PROG) have been studied in 77 breast cyst fluid (BCF) samples. EGF and all tested hormones appeared to be inversely correlated with the intracystic Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ratio (p &lt; 0.001). Consequently, when the BCFs were subdivided according to the Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> ratio, significantly higher levels of EGF, DHEA\u2010S, \u0394\u20104\u2010A, 17\u2010\u03b2\u2010E and PROG were found in Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> &lt; 3 BCFs compared with Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> &gt; 3 BCFs (<jats:italic>p<\/jats:italic>&lt; 0.001 in all cases). Strong direct relationships were found among all steroid hormones when they were correlated to one another (<jats:italic>p<\/jats:italic>&lt; 0.001). Intracystic EGF concentration was directly and significantly correlated with each tested hormone (<jats:italic>p<\/jats:italic>&lt; 0.001). However, the relationship between EGF and steroid hormones appeared to be different in the 2 BCF types (Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> &lt; 3 or &gt;3).<\/jats:p>","DOI":"10.1002\/ijc.2910470409","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:04:44Z","timestamp":1171922684000},"page":"523-526","source":"Crossref","is-referenced-by-count":18,"title":["EGF in breast cyst fluid: Relationships with intracystic androgens, estradiol and progesterone"],"prefix":"10.1002","volume":"47","author":[{"given":"F.","family":"Boccardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Torrisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zanardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pensa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"De Franchis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Barreca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Minuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(90)90222-F"},{"key":"e_1_2_1_3_1","first-page":"5860","article-title":"Epidermal growth factor in breast cyst fluid: relationship with intracystic cation and androgen conjugate content","volume":"48","author":"Boccardo F.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb17800.x"},{"key":"e_1_2_1_5_1","first-page":"105","article-title":"Steroid hormone accumulation in human breast cyst fluid","volume":"41","author":"Bradlow H. 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