{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:11:40Z","timestamp":1759342300777},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5626,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA class\u20101 expression has been investigated by biochemical methods in 14 Burkitt lymphoma (BL) cell lines and the corresponding Epstein\u2010Barr virus (EBV)\u2010transformed lymphoblastoid cell lines (LCL) derived from the same individuals. Selective down\u2010regulation of one or more HLA class\u20101 specificities was demonstrated in 9 out of 14 BL lines. The defect was restricted to a single HLA\u2010A allele in 3 of the lines (BL29, BL72, WW\u20101\u2010BL). Four lines (BL28, BL37, BL41 and Jijoye M13) showed down\u2010regulation of both HLA\u2010A and \u2010C alleles, and one (BL36) failed to express one HLA\u2010C allele. Only one BL line (WW\u20102\u2010BL) had lost one HLA\u2010A and one HLA\u2010B allele. The allele\u2010specific defects were mainly detected in cell lines that had maintained the phenotypic characteristics of the original tumor. Expression of B\u2010cell activation markers and the EBV\u2010encoded nuclear antigen (EBNA)\u20102 correlated with up\u2010regulation of the Cw4 allele in the P79 subline of the BL line Jijoye. Treatment with gamma\u2010interferon (IFN) resulted in full or partial reversion of the HLA class\u20101 defects in some of the cases but had no significant effect in others. This was not due to a cell\u2010line\u2010related unresponsiveness to IFN, nor did it reflect an allele\u2010specific mode of regulation because the same allele could respond differently in different cell lines. The data suggest that defective expression of HLA class\u20101 antigens, which appears to be more prevalent for alleles within the HLA\u2010A and \u2010C loci, is a common feature of BL cell lines. Different regulatory mechanisms appear to be involved.<\/jats:p>","DOI":"10.1002\/ijc.2910470412","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:04:44Z","timestamp":1171922684000},"page":"544-550","source":"Crossref","is-referenced-by-count":48,"title":["aberrant expression of HLA Class\u2010I antigens in burkitt lymphoma cells"],"prefix":"10.1002","volume":"47","author":[{"given":"Monika L.","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico J.","family":"Stam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidde L.","family":"Ploegh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Masucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(88)90120-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(87)90272-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90509-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/329506a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.5.1135"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380618"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2997918"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.139.1.313","article-title":"Identification of a subset of normal B\u2010cells with the Burkitt lymphoma (BL)\u2010like phenotype","volume":"139","author":"Gregory C. 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