{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:07Z","timestamp":1759333267645},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5626,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transformation of retinal neuro\u2010epithelial cells by Rous sarcoma virus (RSV) leads to many alterations in cell phenotype, including changes in cell movement, cell\u2010cell adhesion and protease secretion. To define and quantitate the alterations in cell movement, we analyzed video recordings of cultured cells using the computer\u2010assisted Dynamic Morphology System (DMS). Control neuro\u2010epithelial cells showed very low levels of translocation and membrane activity. After transformation, neuro\u2010epithelial cells exhibited increased membrane activity, although directed cell translocation remained low. Developing retinas also contain a small proportion of Muller glial cells, which were purified by repeated passaging of control cultures. In contrast to neuro\u2010epithelial cells, both control and RSV\u2010transformed glial cells showed high levels of translocation and membrane activity. To analyze how different kinds of cell movement affect invasive behavior, we compared the ability of control and RSV\u2010transformed cells to invade the chorio\u2010allantoic membrane of developing chicken embryos. Control neuro\u2010epithelial cells were not invasive. RSV\u2010transformed neuro\u2010epithelial cells, which showed low levels of translocation as revealed by DMS, were invasive. Similarly, RSV\u2010transformed glial cells were invasive while control glial cells, which translocated, were not invasive. These results suggest that high levels of cell translocation are not necessary for invasion. In addition, the results suggest that elevated membrane activity in neuro\u2010epithelial cells may be important for their invasion.<\/jats:p>","DOI":"10.1002\/ijc.2910470414","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:04:44Z","timestamp":1171922684000},"page":"560-568","source":"Crossref","is-referenced-by-count":10,"title":["Invasion of rous sarcoma virus\u2010transformed retinal cells: Role of cell motility"],"prefix":"10.1002","volume":"47","author":[{"given":"Susann M.","family":"Brady\u2010Kalnay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Soll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Brackenbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.8.3144"},{"key":"e_1_2_1_3_1","first-page":"1826","article-title":"Transepifhelial invasion and intramesenchymal infiltration of the chick embryo chorioallantois by tumor cell lines","volume":"42","author":"Armstrong P. 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