{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:06:57Z","timestamp":1777522017793,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T00:00:00Z","timestamp":1183593600000},"content-version":"vor","delay-in-days":5918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Possible risk factors for cervical cancer were investigated in 645 women, 20\u201349 years of age from Copenhagen, with histologically confirmed cervical cancer or carcinoma <jats:italic>in situ<\/jats:italic> and in 614 controls drawn at random from the female population of the same area. To study the role of the \u201cmale factor\u201d, monogamous cases and controls together with their husbands were invited for further examination. This included a personal interview, a blood sample for analysis of herpes simplex virus antibodies, and a penile swab for papillomavirus analysis. In total, 41 case couples and 90 control couples were enrolled (89% and 92% of eligibles, respectively). The most significant risk determinants were a history of genital warts in the male (RR = 17.9 for ever <jats:italic>vs.<\/jats:italic> never) and ever having used condoms (RR = 0.2). Other potentially important factors, although not statistically significant, were ever having visited prostitutes (RR = 2.6, p = 0.14), circumcision (RR = 0.3, p=0.18), and a history of genital warts in the female (RR = 4.6, <jats:italic>p<\/jats:italic>= 0.09). Having a husband with a history of multiple sexual partners was also associated with an increased crude risk, but when adjustment was made for husband ever having had genital warts, use of condom, and age, no significant excess risk was observed. Human papillomavirus DNA, which was tested for with ViraPap and ViraType, was detected in one of the controls, and in only 2 case husbands. This study points to the importance of \u201chigh\u2010risk males\u201d for the development of cervical cancer in their sexual partner; the results support the infectious nature of the disease.<\/jats:p>","DOI":"10.1002\/ijc.2910480108","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T18:08:21Z","timestamp":1278526101000},"page":"39-44","source":"Crossref","is-referenced-by-count":47,"title":["Case\u2010control study of risk factors for cervical neoplasia in Denmark. I: Role of the \u201cmale factor\u201d in women with one lifetime sexual partner"],"prefix":"10.1002","volume":"48","author":[{"given":"Susanne K.","family":"Kjaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel\u2010Michele","family":"de Villiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerda","family":"Engholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes E.","family":"Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent F.","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsebeth","family":"Lynge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole M.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,5]]},"reference":[{"key":"e_1_2_1_2_1","series-title":"I ARC Scientific Publication 32","volume-title":"The analysis of case\u2010control studies","author":"Breslow N.E.","year":"1980"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(86)90139-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440202"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91215-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.172"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410408"},{"key":"e_1_2_1_8_1","first-page":"205","article-title":"Herpes simplex virus type\u2010specific antibodies detected by indirect and competition ELISA. Comparison of sera from patients with carcinoma of the uterine cervix, age matched controls and patients with recurrent genital herpes","volume":"91","author":"Najem S.N.","year":"1983","journal-title":"Acta path. microbiol. Immunol, scand."},{"key":"e_1_2_1_9_1","volume-title":"Genstal 5 reference manual","author":"Payne R.W.","year":"1987"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198704000-00002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90661-4"},{"key":"e_1_2_1_12_1","first-page":"261","article-title":"ELISA for herpes simplex virus (HSV) type\u2010specific antibodies in human sea using type\u2010heterologous rabbit antibodies","volume":"87","author":"Vestegaard B.F.","year":"1979","journal-title":"Acta path, microbial, scand."},{"key":"e_1_2_1_13_1","first-page":"226","volume-title":"Methods of enzymatic analysis","author":"Vestergaard B.F.","year":"1986"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114238"},{"key":"e_1_2_1_15_1","first-page":"1","volume-title":"Advances in viral oncology","author":"zur Hausen H.","year":"1989"},{"key":"e_1_2_1_16_1","first-page":"11","volume-title":"Herpes and papillomaviruses","author":"Zur Hausen H.","year":"1988"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910480108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910480108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T04:23:04Z","timestamp":1698034984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910480108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4,22]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,4,22]]}},"alternative-id":["10.1002\/ijc.2910480108"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910480108","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4,22]]}}}