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In all these cell lines, SB reduced cell proliferation and changed the morphology of the cells into a fibroblast\u2010like shape. In PLC\/PRF\/5, alpha\u2010fetoprotein production and c\u2010myc expression were inhibited. In contrast, gene expression of albumin, one of the normal liver\u2010cell products, Mid that of integrated hepatitis B virus genome, was increased. In HCC\u2010M and HCC\u2010T, <jats:italic>c\u2010myc<\/jats:italic> expression, which was enhanced In the naive state, was reduced. In HCC\u2010M, <jats:italic>fos<\/jats:italic> expression was inhibited but the expression of N\u2010 and K\u2010<jats:italic>ras<\/jats:italic> genes did not change. SB seemed to induce normal or mature properties of hepatocytes in human hepatoma cell lines.<\/jats:p>","DOI":"10.1002\/ijc.2910480223","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:23:47Z","timestamp":1171923827000},"page":"291-296","source":"Crossref","is-referenced-by-count":45,"title":["Differentiating effect of sodium butyrate on human hepatoma cell lines PLC\/PRF\/5, HCC\u2010M and HCC\u2010T"],"prefix":"10.1002","volume":"48","author":[{"given":"Hidetsugu","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Morizane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatehiro","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Miyaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2976","article-title":"Effect of growth and sodium butyrate on brush border membrane\u2010associated hydrolases in human colorectal cancer cell lines","volume":"45","author":"Chung Y. 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