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Localization variants were also significantly more frequent among the patients (<jats:italic>p<\/jats:italic> &lt; 0.05 for OSMF and &lt; 0.001 for oral cancer patients). The C\u2010band heteromorphism patterns remained comparable in OSMF and in oral cancer patients, with chromosome 1 being the most frequently involved. On correlating the tobacco\/areca\u2010nut chewing habit with the presence of C\u2010band heteromorphism, we observed that C\u2010band heteromorphism was present in 89% of the habit\u2010free oral cancer patients and 80% of the OSMF patients with relatively shorter exposure to this habit, <jats:italic>i.e.<\/jats:italic> &lt; 5 years. This signifies that genetic factors are important in the causation of oral precancerous and cancerous conditions and that polymorphism of the heterochromatic regions does appear to play a role in these conditions.<\/jats:p>","DOI":"10.1002\/ijc.2910480313","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:23:41Z","timestamp":1171923821000},"page":"386-389","source":"Crossref","is-referenced-by-count":5,"title":["Variations in centromeric heterochromatin among patients with pre\u2010malignant and malignant oral diseases"],"prefix":"10.1002","volume":"48","author":[{"given":"Bhavana J.","family":"Dave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit H.","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth G.","family":"Adhvaryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90257-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810515)47:10<2437::AID-CNCR2820471021>3.0.CO;2-Z"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90093-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1983.tb00167.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90154-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90037-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(79)90015-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90035-3"},{"key":"e_1_2_1_10_1","first-page":"403","article-title":"Oral premalignancy","volume":"2","author":"Evenson J. 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