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Seventy\u2010three women with normal cervix, condyloma, low\u2010 and high\u2010grade CIN and squamous carcinoma were evaluated in comparison with 15 persons with vulvar and 9 with penile papillomavirus\u2010assoclated lesions. HPV genotypes were determined by dot\u2010blot hybridization. Non\u2010cervical lesions did not express HR. Condyloma on squamous metaplasia of the cervix and high\u2010grade CIN expressed high levels of HR, particularly PgR (mean 4,086 and 4,518 fmoles\/g tissue, respectively). Cervical squamous carcinoma expressed very low concentrations of PgR in a limited number of cases. High levels of PgR were correlated with high\u2010grade CIN(<jats:italic>p<\/jats:italic> &lt;0.05),HPV16\u201318\u2010associated lesions (<jats:italic>p<\/jats:italic> &lt;0.01) and ER were correlated to HPV6\u201311\u2010related lesions (<jats:italic>p<\/jats:italic> &lt; 0.01). The levels were independent of age, cycle stage and oral contraception. Morphological localization of PgR, using an immunocytochemical method using a monoclonal antibody (MAb) (PR\u2010ICA), showed intense homogeneous staining in the nuclei of the stromal fibroblasts underlying dysplastic epithelium and condyloma on squamous metaplasia. These results suggest that, under <jats:italic>in vivo<\/jats:italic> conditions, sex steroid hormones, particularly progesterone, may act indirectly on HPV\u2010infected epithelial cells and be implicated as co\u2010factors in HPV\u2010related cervical neoplasia. They could explain the relative predisposition to malignant transformation of the cervix as compared with vulvar and penile mucosa.<\/jats:p>","DOI":"10.1002\/ijc.2910480410","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:23:04Z","timestamp":1171923784000},"page":"533-539","source":"Crossref","is-referenced-by-count":59,"title":["Estrogen and progesterone receptors in cervical human papillomavirus related lesions"],"prefix":"10.1002","volume":"48","author":[{"given":"Joseph","family":"Monsonego","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Magdelenat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Catalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Coscas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Zerat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"5176","article-title":"Comparison of an immunocytochemical assay for progesterone receptor with a biochemical method of measurement and immunocytochemical examination of the relationship between progesterone and estrogen receptors","volume":"49","author":"Berger U.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","first-page":"384","article-title":"R\u00e9epteurs st\u00e9r\u00f6diens dans le cancer du col ut\u00e9rin","volume":"69","author":"Bolla M.","year":"1982","journal-title":"Bull. 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