{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:56Z","timestamp":1787063996412,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thymosins \u03b2\n                    <jats:sub>4<\/jats:sub>\n                    and \u03b2\n                    <jats:sub>10<\/jats:sub>\n                    are 2 structurally related polypeptides originally defined in the rat immune system. To date, no truly unambiguous functions have been formally ascribed to these small (&lt;4.9 kDa) acidic proteins. Previous research has demonstrated relationships between expression of these genes and cell growth\/differentiation. These observations prompted the present study which has used cDNA and synthetic oligonucleotide probes in combination with high\u2010performance liquid chromatography (HPLC) to examine the differential expression of these 2 genes in normal and neoplastic human tissues and in the developing human kidney. Low levels of \u03b2\n                    <jats:sub>4<\/jats:sub>\n                    and \u03b2\n                    <jats:sub>10<\/jats:sub>\n                    mRNA species prevailed in normal tissues; in contrast, these gene transcripts were notably more abundant in malignant renal tumors and in the normal human embryonic kidney. These findings show that the thymosin \u03b2\n                    <jats:sub>4<\/jats:sub>\n                    and \u03b2\n                    <jats:sub>10<\/jats:sub>\n                    genes are constitutively expressed at higher levels in embryonic\/neoplastic as compared to normal\/benign tissues and that thymosin in \u03b2\n                    <jats:sub>10<\/jats:sub>\n                    in particular may be a new molecular marker for renal\u2010cell carcinoma as well as other malignancies.\n                  <\/jats:p>","DOI":"10.1002\/ijc.2910480507","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:22:45Z","timestamp":1171905765000},"page":"672-677","source":"Crossref","is-referenced-by-count":72,"title":["Differential expression of thymosin genes in human tumors and in the developing human kidney"],"prefix":"10.1002","volume":"48","author":[{"given":"Alan K.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4489"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-1-69"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single\u2010step method of RNA isolation by acid guanidinium thiocyanate\u2010phenol\u2010chloroform extraction","volume":"162","author":"Chomczynski P.","year":"1987","journal-title":"Anal. 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