{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:14:55Z","timestamp":1791094495940,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1991,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera from 118 women of 33 to over 90 years of age, with or without a history of cervical squamous\u2010cell carcinoma, were examined for the presence of antibodies to HPV\u20106b, HPV\u201016 and HPV\u201018 L1, L2, E4, and E7 gene products by the use of bacterially derived \u03b2\u2010Gal fusion proteins and Western\u2010blot analysis. Among the cervical cancer patients, 29\/46 (63.0%) were positive for antibodies to E4 and\/or E7 of HPV\u201016 and\/or E7 of HPV\u201018. In contrast, only 2 of 31 (6.5%) non\u2010genital cancer patients and 4 of 41 (9.8%) healthy individuals were antibody\u2010positive for HPV\u201016 E4 or E7, while antibodies to the homologous proteins of HPV\u201018 could not be detected. Prevalence rates of antibodies to the HPV\u201016\/18 late proteins were 25\/46 (54.3%) in the cervical carcinoma group, 13\/31 (41.9%) among women with non\u2010genital cancer types, and 18\/41 (43.9%) among normal, healthy individuals. Antibodies to HPV\u20106b late gene products ranged between 6.5% and 12.2% in the different patient groups. Antibodies to HPV\u20106b E4 and E7 were detected only once. By studying an additional control group of 207 women with a different age distribution, age\u2010dependence of antibodies to HPV gene products could be ruled out. Whereas antibodies to late proteins may indicate that, regardless of clinical stage, HPV infections are widespread among the female population, the striking difference between the prevalence rates of antibodies to early proteins of HPV\u201016 and HPV\u201018 among cervical cancer patients and controls (<jats:italic>p<\/jats:italic> &lt; 0.001) supports the idea of the involvement of these virus types in carcinogenesis of the cervix.<\/jats:p>","DOI":"10.1002\/ijc.2910480509","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:22:45Z","timestamp":1171923765000},"page":"682-688","source":"Crossref","is-referenced-by-count":38,"title":["Occurrence of antibodies TO L1, L2, E4 and E7 gene products of human papillomavirus types 6b, 16 and 18 among cervical cancer patients and controls"],"prefix":"10.1002","volume":"48","author":[{"given":"Heinrich G.","family":"K\u00f6chel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masyar","family":"Monazahian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"H\u00f6hne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Thomssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Teichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Arendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Thomssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/j.1460-2075.1984.tb01944.x","article-title":"A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical carcinomas","volume":"3","author":"Boshardt M.","year":"1984","journal-title":"EMBO J."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90343-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03405.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198404053101403"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1128\/jvi.40.3.932-935.1981","article-title":"Molecular cloning of viral DNA from genital warts","volume":"40","author":"De Villiers E. 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